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Vitamins, Nutrients, Herbs and Supplements For discussion about vitamins, vitamin deficiency, herbal remedies and other supplements. |
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06-15-2013, 09:17 AM | #21 | |||
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Wisest Elder Ever
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Here is a quote from Wiki on this disorder:
Quote:
http://en.wikipedia.org/wiki/Hypophosphatasia People with this genetic error, will show very low alkaline phosphatase levels, on testing, and many other obvious problems with bone formation. This is a very rare disorder. I hope for your sake this is not your problem. Vitamin B6 metabolism is very complex. There can be errors in many points along the pathways it takes: http://www.kegg.jp/kegg-bin/show_pathway?map00750 Pyridoxine is near the center of the map, and is part of a square showing formation of pyridoxal...and to the left is the fate of pyridoxal. The rectangular boxes, have numbers in them, and those are enzymes that have been coded so far. This wiki article explains the chemistry further: https://en.wikipedia.org/wiki/Pyridoxal_phosphate At one time I read that about 300 reactions depend on P5P... so this just adds to the complexity. The most notable pyridoxine error in humans is B6 dependency. These individuals require really high doses of B6 beyond normal to survive. This is a genetic error and also very rare. I only provide these links and topics to illustrate how complicated B6 is in the body. And the medical community does not really have a good grasp on all the potential problems involving errors of utilization with it. One of the primary sources for B6 is meat. Bananas are quite high too and most breakfast cereals and potatoes. Try avoiding these dietary sources, read all labels of other foods you consume, and get retested in 3 to 6 months and see what your P5P is then. It is possible there is a source in your food that you have overlooked. This is the most common source. If you are still high after doing a dietary makeover....then genetic issues are what is left.
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