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Old 05-05-2008, 11:18 AM #11
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Default we had some papers on carnitine and ADHD...

on the Old Braintalk before the crash....

Quote:
Comment: The results of this study indicate that supplementation with L-carnitine significantly decreases attention problems and aggressive behavior in boys with ADHD. Although the mechanism of action is not clear, low plasma carnitine concentrations have been found in some children with ADHD. Because this nutrient plays a key role in energy metabolism, correction of carnitine deficiency might enhance overall performance, thereby improving attention span and other aspects of behavior. Carnitine is also involved in blood-sugar regulation, which may be abnormal in some children with ADHD. A relatively large dose of L-carnitine was used in the present study. Additional research should focus on whether lower doses would be effective, when used as a component of a comprehensive dietary and nutritional-supplement regimen.

Van Oudheusden LJ, Scholte HR. Efficacy of carnitine in the treatment of children with attention-deficit hyperactivity disorder. Prostaglandins Leukot Essent Fatty Acids 2002;67:33-38.
and this:
Quote:
Med Hypotheses. 1998 Jun;50(6):497-500. Related Articles, Links


Autism: a mitochondrial disorder?

Lombard J.

Westchester Square Medical Center, New York, NY 10461, USA.

Autism is a developmental disorder characterized by disturbance in language, perception and socialization. A variety of biochemical, anatomical and neuroradiographical studies imply a disturbance of brain energy metabolism in autistic patients. The underlying etiology of a disturbed bioenergetic metabolism in autism is unknown. A likely etiological possibility may involve mitochondrial dysfunction with concomitant defects in neuronal oxidative phosphorylation within the central nervous system. This hypothesis is supported by a frequent association of lactic acidosis and carnitine deficiency in autistic patients. Mitochondria are vulnerable to a wide array of endogenous and exogenous factors which appear to be linked by excessive nitric oxide production. Strategies to augment mitochondrial function, either by decreasing production of endogenous toxic metabolites, reducing nitric oxide production, or stimulating mitochondrial enzyme activity may be beneficial in the treatment of autism.

Publication Types:
Review
Review, Tutorial

PMID: 9710323 [PubMed - indexed for MEDLINE]
here is a more modern paper:
Quote:
1: J Child Adolesc Psychopharmacol. 2007 Dec;17(6):791-802.Click here to read Links
Acetyl-L-carnitine (ALC) in attention-deficit/hyperactivity disorder: a multi-site, placebo-controlled pilot trial.
Arnold LE, Amato A, Bozzolo H, Hollway J, Cook A, Ramadan Y, Crowl L, Zhang D, Thompson S, Testa G, Kliewer V, Wigal T, McBurnett K, Manos M.

The Ohio State University Nisonger Center, Columbus, OH, USA.

OBJECTIVE: To determine whether acetyl-L-carnitine (ALC), a metabolite necessary for energy metabolism and essential fatty acid anabolism, might help attention-deficit/hyperactivity disorder (ADHD). Trials in Down's syndrome, migraine, and Alzheimer's disease showed benefit for attention. A preliminary trial in ADHD using L-carnitine reported significant benefit. METHOD: A multi-site 16-week pilot study randomized 112 children (83 boys, 29 girls) age 5-12 with systematically diagnosed ADHD to placebo or ALC in weight-based doses from 500 to 1500 mg b.i.d. The 2001 revisions of the Conners' parent and teacher scales (including DSM-IV ADHD symptoms) were administered at baseline, 8, 12, and 16 weeks. Analyses were ANOVA of change from baseline to 16 weeks with treatment, center, and treatment-by-center interaction as independent variables. RESULTS: The primary intent-to-treat analysis, of 9 DSM-IV teacher-rated inattentive symptoms, was not significant. However, secondary analyses were interesting. There was significant (p = 0.02) moderation by subtype: superiority of ALC over placebo in the inattentive type, with an opposite tendency in combined type. There was also a geographic effect (p = 0.047). Side effects were negligible; electrocardiograms, lab work, and physical exam unremarkable. CONCLUSION: ALC appears safe, but with no effect on the overall ADHD population (especially combined type). It deserves further exploration for possible benefit specifically in the inattentive type.

PMID: 18315451 [PubMed - indexed for MEDLINE]
and:
Quote:
: Prostaglandins Leukot Essent Fatty Acids. 2002 Jul;67(1):33-8.Click here to read Links
Efficacy of carnitine in the treatment of children with attention-deficit hyperactivity disorder.
Van Oudheusden LJ, Scholte HR.

Department of Pediatrics, Westfries Gasthuis, Hoorn, The Netherlands. oudheusden@wxs.nl

To determine safety and the efficacy of carnitine treatment in children with attention-deficit hyperactivity disorder (ADHD). The ADHD behavior was observed by parents completing the Child Behavior Checklist (CBCL) and by teachers completing the Conners teacher-rating score, in a randomized, double-blind, placebo-controlled double-crossover trial. In 13/24 boys receiving carnitine, home behavior improved as assessed with the CBCL total score (P < 0.02). In 13/24 boys, school behavior improved as assessed with the Conners teacher-rating score (P < 0.05). Before treatment, the CBCL total and sub-scores were significantly different from those of normal Dutch boys (P < 0.0001). Responders showed a significant improvement of the CBCL total scores compared to baseline (P < 0.0001). In the majority of boys no side effects were seen. At baseline and after carnitine treatment, responders showed higher levels of plasma-free carnitine (P < 0.03) and acetylcarnitine (P < 0.05). Compared to baseline, the carnitine treatment caused in the responsive patients a decrease of 20-65% (8-48 points) as assessed by the CBCL total problem rating scale. Treatment with carnitine significantly decreased the attention problems and aggressive behavior in boys with ADHD. Copyright 2002 Elsevier Science Ltd.

PMID: 12213433 [PubMed - indexed for MEDLINE]
My impressions from this original poster was that he was seeking improved
libido. He had increased attention as a side effect.

He does not say he HAS ADD/ADHD or TS...

The autism community is now using methyl B12 and methylfolate as well as carnitine and CoQ-10 to enable better mitochondrial functions. New research is hinting that vaccine injury occurs to the mitochondria and may be a trigger to autism in children.
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Old 05-07-2008, 08:47 AM #12
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Default Thought on Tyrosine

Tyrosine and boy did that help me. However i began to get a pain in my liver near my sternum. It is definitely correlated because when I stopped the pain disappeared.
My questions are 3 fold. 1. Does anyone know why Tyrosine would do that?


Hi, I'm new here and happen to come across your posting. One thought on Tyrosine....I've read that tyrosine helps move fat out of your liver....perhaps you were experiencing a bit of a detox from the amino acid. I know when my husband starting taking histidine he had a severe reaction to it because for the first time his lungs were functioning at a healthier level.....we decided to let him go through it because we figured his body was actually now trying to rid his body of the old toxins that he was unable to do before......it lasted for about 7-8 days......it was horrible but then one day it all cleared out and he felt much better! It does seem to make sense that if certain organs haven't been functioning as good as they should be, when they get a kick start things start moving. I know when I've done a kidney flush they ache for a few days before I start to feel good again.

Anyways...good luck to you!!!! I know it can all be challenging!!!
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Old 06-24-2009, 09:38 AM #13
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Default Methadone withdraw

Hello,I,m having a difficult time now with my motivation towards everything I feel like one poster said "Blaaa".I was a heroin addict for ten years.I was on methadone for the last year and tapered down to zero.I know my dopamine receptors are really messed up.I'm trying to find some thing to help restore/balance my levels without impeding the natural restoration of them.
Is there some thing that I could take now to help then taper back?I'm drug free now and don't know how long I can stay that way without some relief from my mental state.Please help
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Old 06-26-2009, 10:06 AM #14
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Well,I'm trying tyrosine and it seems to help a little.I'm taking B-6 also because it helps transform the tyrosine.I'll check back in later
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Old 06-30-2009, 08:30 AM #15
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I failed again,I'm not sure how I can beat this I guess I'm just doomed to a life addicted to opiates.thanks for the input anyway.
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Old 07-01-2009, 08:35 AM #16
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Quote:
Originally Posted by Allmessedup View Post
I failed again,I'm not sure how I can beat this I guess I'm just doomed to a life addicted to opiates.thanks for the input anyway.
you have failed only if that is what you want......most persons backslide on occassion when trying to form new habit/break old ones
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Old 09-12-2009, 04:47 PM #17
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Smile

I don't know about taking tyrosine tablets but am checking into it myself. I am going to try it and watch for adverse reactions after reading your post. Have you heard of the book 'A Younger, Thinner You'? I have just begun to read it and it is how I learned about my dopamine deficiency. My sister is on the diet, she has had a weight issue her whole life and says that this is the miracle she's been waiting for. She is losing weight and feels great.

Best,

Julia
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Old 02-03-2010, 05:05 PM #18
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Default Hello

Ive was just watching Fox news yesterday and i saw that Restless Leg Syndrome and ED are now connected. I researched a little and found that both are linked to a dopamine deficiency. I have episodes of RLS at least 5-8 times a month i cant stand it. Also i get about 5 to 8 hrs of sleep a night. Being in the Navy sleep is not always as it should be. My wife tells me i need a sleep study done. i can get a fuyll 8 hrs of sleep and ill be watching tv or even talking and pass out at like 3 pm, i feel like iam always tired and working out is hard for me to do. And i do have a good reason to be motivated if i cant lose weight and keep it off i will be kicked out of the Navy. I do try and eat right but it seems that weight always creeps back on me. One thing that makes sense to me is that ever since i can remember ive been highly addicted to cottage cheese. i read that it helps make dopamine, could that be my body telling me that i have low dopamine lvls. I also have been smoking on and off since i was 12yrs old iam 29 now and iam addicted to chewing tobacco and smoking and i drink alot of diet pepsi. I need help iam going to go to medical on base very soon but the thought of going on Meds especially ones prescribed by military doctors.
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Old 02-03-2010, 06:48 PM #19
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Lightbulb

Diet Pepsi, has aspartame in it...this contains aspartic acid, which is a neuro-excititory amino acid. If you cut back on that, you might see some improvement.

Magnesium is also useful in RLS.... low levels will cause muscle twitching and cramping. It is listed by many doctors as something to try before using drugs.

I have a magnesium thread on the first page here. It explains how to select the right dose, and the best oral forms (magnesium oxide is useless).
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These forums are for mutual support and information sharing only. The forums are not a substitute for medical advice, diagnosis or treatment provided by a qualified health care provider. Always consult your doctor before trying anything you read here.
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Old 08-25-2011, 02:47 PM #20
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Default Piggy-backing on the low dopamine questions...

Hi,
This is my first time on this forum but these posts have been so helpful. I am pretty, sure based on my own research that I have low dopamine levels. I am taking Cymbalta for Chronic Fatigue/Fibromyalgia symptoms and also Synthroid for low thyroid. And the Cymbalta really gets rid of most of the achiness that I experience without it. However, I am always tired, no matter how much sleep I get and I just lack energy for anything it seems. I exercise, do yoga, take supplements and nothing seems to help. I have had no luck with the dr's finding anything wrong though. I am thinking of trying Wellbutrin but I did not know you could get Tyrosine as a supplement. Can you get it at the health food store? It is just labeled Tyrosine?

Thanks for all your help on this!!!
Lee
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