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Old 10-29-2008, 05:14 PM #61
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Originally Posted by daniella View Post
I have a ? I take 2 fish oil pills daily which is 2400mg total. I still am suffering from severe dry eye/skin/and my pain from the rsd/pn. Anyhow at times I was taking flaxseed but now haven't been. Can I add more fish oil pills or flaxseed pills in addition to what I am taking or is this the upper limit the 2400 mg in supplements?
2400 mg is not the "upper limit" of fish oil. That is 2.4 Grams. Clinical trials for mood dsorders, for instance, routinely use 2-4 Grams (up to 4000 mg).

However, you might wish to check your vitamin D and thyroid levels.
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Old 10-29-2008, 06:08 PM #62
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Arrow 2 capsules

may say 2.4grms...but that is not the amount of active ingredient in a typical fish oil.

The EPA and DHA levels are much less.
It is confusing but some papers mean 2 grms of EPA etc, not the total weight of the capsule itself.

for example ..RX Lovaza:
Quote:
Each 1-gram capsule of LOVAZA contains 465 mg EPA and 375 mg DHA, the active fatty acids proven to lower very high triglycerides
My double strength Costco fish oil has 684 mg of combined EPA/DHa in a 1200 mg capsule. A standard strength fish oil has about 1/2 of this amount.

The papers don't always clarify the doses, and labels can be confusing.
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Old 10-30-2008, 12:23 PM #63
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Jaspar and Mrs D thanks. My D level and thyroid is fine. I know when I saw that holistic doctor he wanted me to take a lot but also felt that way on other supplements. So I should I take 2 fish oil and 2 flaxseed pills? That would give me 2000mg of flax and 2400mg of fish oil. I have no idea the conversion. I wish they would make this easier for the consumer. I remember this with magnesium too.
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Old 10-30-2008, 12:25 PM #64
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Lightbulb yes, sounds fine.

Make sure you take with food.

You will need B6 too for conversion of the fats.
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Old 11-04-2008, 02:38 PM #65
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Quote:
Originally Posted by mrsD View Post
may say 2.4grms...but that is not the amount of active ingredient in a typical fish oil.

The EPA and DHA levels are much less.
It is confusing but some papers mean 2 grms of EPA etc, not the total weight of the capsule itself.

for example ..RX Lovaza:


My double strength Costco fish oil has 684 mg of combined EPA/DHa in a 1200 mg capsule. A standard strength fish oil has about 1/2 of this amount.

The papers don't always clarify the doses, and labels can be confusing.
The Omega Capsules that I take have 600mg EPA, 480 mg of DHA, 120 mg of other essential fatty acids, 1200 mg of Omega 3 fatty acids, and 220 mg of an Omega 5 6 9 complex (70% pomegranate seed oil, evening primrose seed oil, borage seed oil and organic flax seed oil)
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Old 12-11-2008, 03:23 PM #66
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Lightbulb new paper on cardio-protective effects:

I just found this today... doses are not listed, but it is a very positive article:

Quote:
Lipids Health Dis. 2008 Oct 15;7:37.Click here to read Click here to read Links
Essential fatty acids and their metabolites could function as endogenous HMG-CoA reductase and ACE enzyme inhibitors, anti-arrhythmic, anti-hypertensive, anti-atherosclerotic, anti-inflammatory, cytoprotective, and cardioprotective molecules.
Das UN.

UND Life Sciences, 13800 Fairhill Road, #321, Shaker Heights, OH 44120, USA. undurti@hotmail.com

Lowering plasma low density lipoprotein-cholesterol (LDL-C), blood pressure, homocysteine, and preventing platelet aggregation using a combination of a statin, three blood pressure lowering drugs such as a thiazide, a beta blocker, and an angiotensin converting enzyme (ACE) inhibitor each at half standard dose; folic acid; and aspirin-called as polypill- was estimated to reduce cardiovascular events by approximately 80%. Essential fatty acids (EFAs) and their long-chain metabolites: gamma-linolenic acid (GLA), dihomo-GLA (DGLA), arachidonic acid, eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA) and other products such as prostaglandins E1 (PGE1), prostacyclin (PGI2), PGI3, lipoxins (LXs), resolvins, protectins including neuroprotectin D1 (NPD1) prevent platelet aggregation, lower blood pressure, have anti-arrhythmic action, reduce LDL-C, ameliorate the adverse actions of homocysteine, show anti-inflammatory actions, activate telomerase, and have cytoprotective properties. Thus, EFAs and their metabolites show all the classic actions expected of the "polypill". Unlike the proposed "polypill", EFAs are endogenous molecules present in almost all tissues, have no significant or few side effects, can be taken orally for long periods of time even by pregnant women, lactating mothers, and infants, children, and adults; and have been known to reduce the incidence cardiovascular diseases including stroke. In addition, various EFAs and their long-chain metabolites not only enhance nitric oxide generation but also react with nitric oxide to yield their respective nitroalkene derivatives that produce vascular relaxation, inhibit neutrophil degranulation and superoxide formation, inhibit platelet activation, and possess PPAR-gamma ligand activity and release NO, thus prevent platelet aggregation, thrombus formation, atherosclerosis, and cardiovascular diseases. Based on these evidences, I propose that a rational combination of omega-3 and omega-6 fatty acids and the co-factors that are necessary for their appropriate action/metabolism is as beneficial as that of the combined use of a statin, thiazide, a beta blocker, and an angiotensin converting enzyme (ACE) inhibitor, folic acid, and aspirin. Furthermore, appropriate combination of omega-3 and omega-6 fatty acids may even show additional benefits in the form of protection from depression, schizophrenia, Alzheimer's disease, and enhances cognitive function; and serve as endogenous anti-inflammatory molecules; and could be administered from childhood for life long.
PMID: 18922179 [PubMed - in process]
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Old 12-12-2008, 09:26 PM #67
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Default More questions

I have an Rx for Lovaza for heart health, but know Mrs. D. uses the Costco brand that is enteric coated. I had also read that some of the better fish oils are more readily absorbed than capsules. Is one form better than the other for absorbability and metabolization by our bodies? Also, what are the cofactors needed for metabolization of fish or flax oil? I have been reading all of your past and current posts, Mrs. Doubtfyre, but am having trouble putting all of the facts together in a brain absorbable form. . .
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Old 12-13-2008, 07:47 AM #68
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Lightbulb I am not aware of "more absorbable fish oil"

All the fish oils I know of are oils. Hence they are best
absorbed with food present. The bile released at mealtimes emulsifies the oil and improves absorption.

There are some liquid emulsified oils.
Here is an article about Coromega:
http://www.coromega.com/01What/f_bio...ty/f_body.html

Whether this is necessary for most people remains questionable. The emulsified forms are more expensive, and were mostly used by people who couldn't swallow large capsules, and for children.

You can use your Lovaza. My comments are about the hype surrounding it...which may not be exactly true, to account for its increased price. If your insurance pays for it, then the price is not an issue. I do like the fact that the new nutraceuticals that the drug industry are making like Lovaza educate doctors more and help everyone get access to fish oil or other useful things. But the cost to the patient involved is unpleasant IMO.

For example my insurance is going up in January, as I assume many others will be affected as well.
The most reasonable way for me to obtain an RX medication is by mail order. A 3 month supply for me is going up to $65. So a 3 month supply of Lovaza would cost far more than a 3 month supply of
double strength fish oil over the counter. So even WITH insurance people may be paying more for Lovaza.
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Last edited by mrsD; 12-13-2008 at 10:33 AM.
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Old 04-23-2009, 10:32 AM #69
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Lightbulb bumping for a new study:

There is a new study being shared now that is very interesting.

http://www.sciencedaily.com/releases...0419133844.htm

Quote:
The research team led by Dr. Bazan found that the omega three fatty acid, docosahexaenoic acid (DHA), protects cells from this defect....."These experiments provide proof of principle that neuroprotectin D1 can be applied therapeutically to combat various neurodegenerative diseases," says Dr. Bazan. "Furthermore, this study provides the basis of new therapeutic approaches to manipulate retinal pigment epithelial cells to be used as a source of NPD1 to treat patients with disorders characterized by this mutation like Parkinson's, Retinitis Pigmentosa and some forms of Alzheimer's Disease."
I suspect we will see a drug form of this in the near future.

In the meantime, take those fish oil caps, or at least DHA.
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Old 04-23-2010, 04:10 PM #70
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Lightbulb

Here is a new study showing Omega-3s from fish and supplements may stave off colon cancer in white patients:

http://news.yahoo.com/s/nm/20100423/...s_omega_cancer

The African American study subjects did not show statistical improvement however in this study.

It is another step in the direction of good preventive help for major diseases of aging.
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