How much d-chiro inosito to make a dent in metablic syndrome?
Thank you.

there is a paper....
 

quoted on one of those two supplier sites, from PubMed.

For overweight women with metabolic syndrome the paper used 1200mg daily.

For lean women the dose was 600mg daily.

1200 mg daily puts you into mega bucks territory. About $85 a month.

I am going to do the 1200 for 3 months, then have my retests.
I have the orders in my wallet in fact!

Women with metabolic syndrome do not ovulate. So I guess the prices reflect the desperate need and not the real value of the supplement. I feel like it is a form of highway robbery!

If this works for me...the upside is:
1)correction of the metabolic problems without using drugs which do not work without tradeoffs(side effects). d-chiro is a natural substance our bodies use...not a drug...but it is skewed by the metabolic syndrome process.

2) avoiding frank diabetes, which I am on the borderline of.

My A1C is still very low and good, so I am not quite in trouble "yet"...but it IS coming.

here is another link...to chiro inositol:
 

This blog has more links:

http://terveys.blogspot.com/2008/05/...-inositol.html

and this:
http://aladdin.wustl.edu/ocfr/Resear...+Endocrinology

This article was written BEFORE the two OTC supplements became available:
http://www3.fertilethoughts.com/foru...d.php?t=379227

Thanks for this excellent information mrsD.

My DH was taking Atorvastatin (Lipitor) but one of his blood tests rose abnormally high.....(I think it was his CRP). His GP said that hubby's muscles were dying and so ceased the Lipitor.

He now takes Ezetrol (Ezetimibe) 10mgs at night. Will this medication harm his body in the same way as the Atorvastatin did?

in the US
 

this drug is called Zetia. I have read that there is a risk of muscle injury with it too....but...here are the FDA medwatch reports for it:

http://patientsville.com/medication/...de_effects.htm

I used this for 6mos, and got no changes. In fact my cholesterol went UP. I did have some GI upsets with it too.
But it does work for some people.

It appears that the muscle damage side effects are lower with Zetia. Some of the effects on that site, reflect the other drugs the patient was also taking. So the single users are more
accurate IMO.

You might find Dr. Cohen's book very helpful~~
My doctor wanted to read it in fact! So I loaned it to her. I probably will never see it again. :rolleyes:

http://www.medicationsense.com/statin_drugs_book.html

In this book are explanations of other factors that may be more predictive of cardiovascular incidents than cholesterol levels:
c-reactive protein
lipoprotein A
inflammation
low intake of antioxidants

So.... with hubby's elevated CRP due to the Lipitor.... he was more at risk on the drug than off it?

Are you referring to the Zetia? There is some risk, but not as high as it would be for Lipitor. It would be best to get a
CPK test about 3-6mons after starting Zetia, to see if it is affecting it.

Personally I think certain people are more at risk to CPK elevations than others. With the research into mitochondrial damage becoming more complete...we see mito issues with vaccine damage in autism now as well. The thought is that some people have recessive genes for mitochondrial disorders and only express damage when a big thing (drug/vaccine/illness) comes along to set it off. I read a paper a long time ago (about 10 yrs ago) stating that many people have recessive genes for mito disorders and begin expressing them when they get older (over 40-50).

There are many drugs that damage mitochondria.

http://www.rsc.org/chemistryworld/Ne...y/25020801.asp

http://www.mail-archive.com/sustaina.../msg73462.html

With all the reading I do online, and searching...it seems we always come back to this: mito damage.

In fact Dr. Bruce Ames believes that mito damage of simple aging can be diminished with certain nutrients:

http://www.bruceames.org/

So it is possible your husband has a genetic predisposition to
mito damage. I sure know MY doctor argues with me about this all the time. This week she said she takes 20mg Lipitor herself with no problem. And my response to that? Good for you, but you are NOT me! I don't want to take that risk right now. (I couldn't really tell her that she is not as sharp as she once was, either! but she isn't, and I think Lipitor is HER problem.)

Thank you mrsD, and it was his CK that was elevated. I remember thinking at the time it was a test that was formerly used to check for heart attacks.

I was actually talking about the Lipitor, but you've clarified that very nicely for me. He'll be having blood tests done next week so I'll ask his GP to add a CK level to the list.

yes, that test
 

will also show elevation for heart attacks. We call it CPK here.
It will also elevate during a mito attack in patients with mito disorders.

Anyone with elevated CPK should NEVER take statins.
It the rhabdo becomes severe, the byproducts of the muscle breakdown destroy the kidneys and may result in death if severe. Statins also cause liver damage in sensitive patients.

Policosanol
 

This supplement has very mixed reviews.

I am very hesitant to suggest it at this time. But some multivitamin manufacturers do include it in their products...
Like One-A-Day.

The problem with it, is that there are two sources..one from Cuba which was thought to be better, and other types since the embargo on Cuba made the sugarcane form impossible to get.
Now there is a question that the Cuban studies were flawed.

This article is about the best I could find on this subject:

http://altmedicine.about.com/od/poli...olicosanol.htm

Here is a 2008 study that found that policosanols were not effective:
So at this time it appears to not be a good investment for those seeking non-drug interventions.