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Old 11-18-2006, 10:19 PM #1
OnThe Road Back OnThe Road Back is offline
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Default B12 shots and acne?

Hi all:
I'm currently receiving B12 shots to address a diagnosed deficiency. Since I began the shots a few months ago, I noticed my skin breaking out like a teenager. Has anyone else had this happen or heard of it?
By the way, I haven't eaten any chocolate or changed my diet in any way.
Thanks!
Sara
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"Thanks for this!" says:
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Old 11-18-2006, 11:11 PM #2
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Default Rare thing and should be easily taken care of

by taking vitamin E. I would make sure it is the better type with gamma and others. Apparently it was found a long time ago that some who lacked sufficient E would get acne when their body started to work with the B12 it needs.

Taking other nutrients in reasonable amounts is important, because if something is lacking, the body can't do its best. In addition, the body draws more heavily on some nutrients when it is repairing.

Best wishes,

rose
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Old 11-19-2006, 02:36 PM #3
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Thanks, Rose. I will look into Vit. E supplemetation. I also wonder about the best diet to aid nerve regeneration, since my B12 (and B6) deficiency caused my peripheral neuropathy. I want to do all I can to get better.
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Old 11-20-2006, 09:44 AM #4
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Lightbulb B12 and acne...

Sorry to be late to this thread, but I have been working alot more than usual, and just not on line long enough to research this for you.

Here is a common list of drugs/agents that have shown acne potential:
Quote:
* oral steroids
* contraceptive agents: medroxyprogesterone injection (Depo-Provera)
* oral contraceptives that reduce sex hormone binding globulin (SHBG)
* testosterone
* anabolic steroids including danazol, stanozolol
* halogens (iodes, chlorides, bromides, halothane)
* anti-epileptics (carbamazepine, phenytoin, phenobarbital)
* Anti-tuberculosis drugs (ethionamide, isoniazid, rifampicin)
* anti-depressants (lithium, amoxapine)
* cyclosporin
* B vitamins (B12, cyanocobalamin)
There are anecdotal reports, many of them old, of cyanocobalamin reactions that look like acne, but are a specific type of lesion:
Quote:
Cutis. 1979 Aug;24(2):210-1. Links
Vitamin B-12 induced acnes.

* Dupre A,
* Albarel N,
* Bonafe JL,
* Christol B,
* Lassere J.

A type of acne induced by vitamin B-12 deserves a special place among acneiform eruptions. The eruption is monomorphic and of a particular type. It consists of voluminous folliculitis lesions which develop acutely after the first injections of vitamin B-12 and disappear rapidly when treatment is discontinued. The etiologic and pathogenic mechanisms of the disease are not know.

PMID: 157854 [PubMed - indexed for MEDLINE]
This paper is interesting, because it does not say what megadoses were
required:
Quote:
Cutis. 1991 Aug;48(2):119-20. Links
Acneiform eruption due to "megadose" vitamins B6 and B12.

* Sherertz EF.

Department of Dermatology, Bowman Gray School of Medicine, Winston-Salem, North Carolina 27103.

Medications and other exogenous factors are known to be capable of exacerbating acne or precipitating acneiform eruptions. This case illustrates an eruption resembling acne rosacea that was temporally associated with daily ingestion of high-dose B vitamin supplement. The eruption failed to respond to the usual treatment regimens for rosacea, but promptly improved when use of the vitamin supplement was discontinued.

PMID: 1834437 [PubMed - indexed for MEDLINE]
Most vitamin supplements do not have megadoses of B12 in them. But they typically do have cyano version.
Here is another:
Quote:
MMW Munch Med Wochenschr. 1976 Feb 6;118(6):155-60. Links
[The problem of vitamin B6/B12 acne. A contribution on acne medicamentosa (author's transl)]
[Article in German]

* Braun-Falco O,
* Lincke H.

Deterioration of acne vulgaris or eruption of an acneiform exanthema could be established during treatment with vitamin B6 and/or vitamin B12 in 14 patients. Females were by far the more frequently affected. The appearance of skin symptoms, even outside the age groups typically affected by acne vulgaris is characteristic. The clinical appearance of acneiform exanthema occurring during treatment with vitamin B6 or B12 consists of loosely disseminated small papules or papulopustules on the face (especially on the forehead and chin), on the upper parts of the back and chest and spreading to the upper arm. The pathogensis of the change is not yet certain. The acneiform rash generally fades within a short time after vitamin B6 or vitamin B12 treatment has been stopped.

PMID: 130553 [PubMed - indexed for MEDLINE]

B6 is capable of causing a skin reaction with sun exposure:
Quote:
J Dermatol. 1996 Oct;23(10):708-9. Links
Photoallergic drug eruption due to pyridoxine hydrochloride.

* Tanaka M,
* Niizeki H,
* Shimizu S,
* Miyakawa S.

Division of Dermatology, Kawasaki Municipal Hospital, Japan.

Photoallergy to vitamin B6 is very rare; only a few cases of contact dermatitis and one case of photosensitive dermatitis due to pyritinol have been reported. We report here the first case of photoallergic drug eruption due to pyridoxine hydrochloride. A 71-year-old man developed papulo-squamous erythemata which were confined to sun-exposed sites. Photopatch testing, together with the clinical course, was helpful in reaching the initial diagnosis; this was confirmed by an oral challenge test. Photoallergic drug eruption due to vitamin B6 should be considered a rare cause of photosensitive dermatitis.

PMID: 8973037 [PubMed - indexed for MEDLINE]
Here is an example of acne caused by inhalers containing steroids:
Quote:
Clin Exp Dermatol. 1993 Mar;18(2):148-50. Links
Acne induced by inhaled corticosteroids.

* Monk B,
* Cunliffe WJ,
* Layton AM,
* Rhodes DJ.

Department of Dermatology, Bedford Hospital, UK.

Four cases of acne apparently induced by inhalation of potent corticosteroids prescribed for the treatment of asthma are described. In one case there appeared to be a dose-dependent relationship. While acne induced by topical or systemic administration of corticosteroids is well recognized, acne following inhaled corticosteroids has not previously been reported.

PMID: 8481992 [PubMed - indexed for MEDLINE]
All of these reports involve low numbers of patients, and a wide span of time.

Some people just cannot tolerate cyano version of B12. You know, this is a man-made product and not natural to the body.

If you suspect your acne is triggered by cyano version, you could switch to
hydroxy injection, or try the oral methyl form.

Other situations can lead to acne "attacks". Low zinc is one. Low intake of Vit A, C, E, and Selenium, also impact the skin.

Also notice in the list at the beginning of this post, that HORMONES are typically triggers. Many women today have PCOS, and the attendant elevated androgen levels, and if this is a possibility, then acne can be caused by this, or triggered by it. You can have blood tests drawn for androgens, and this will tell you if you are experiencing this effect. PCOS (polycystic ovary syndrome) is more common today than ever and being diagnosed more accurately.

Normal dosing of methylcobalamin has not appeared in the literature as causing acne, that I have found.

Lack of omega-3 in the diet, also leads to acne. My son's acne resolved with flax oil, evening primrose and fish oil daily (one capsule of each). A diet high in damaging transfats will also show up in the skin, so eliminating these harmful fats (most restaurants still use them) is important.

Since medical resources now list daily 1,000 mcg (1mg) doses of methylcobalamin as equivalent to the shots, it might be worth a trial of switching to the oral form. It only costs .09 a day.
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Old 11-20-2006, 10:48 AM #5
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MrsD, Thank you!
I had a strong feeling my skin problems were related to the B12 shots and possible also the high B6 oral doses. I may try to tolerate the chin breakouts since I want to heal so deperately. Or maybe I will try the oral B12 and see if it helps. I appreciate the research you provided. Very thorough and so helpful.
Have a great holiday!
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Old 11-20-2006, 05:07 PM #6
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Red face I sure missed the boat on that one.

I should have mentioned the type of B12.

Certainly, anyone who can use methylcobalamin (or even has access only to hydroxocobalamin and cyanocobalamin) would not to be relying on cyanocobalamin. Cyanocobalamin has saved countless lives, but better forms have been available for many years and the form is extremely important to some.

rose
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Old 07-11-2007, 01:51 PM #7
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Default Methylcbalamin Caused Acne

Quote:
Originally Posted by OnThe Road Back View Post
Hi all:
I'm currently receiving B12 shots to address a diagnosed deficiency. Since I began the shots a few months ago, I noticed my skin breaking out like a teenager. Has anyone else had this happen or heard of it?
By the way, I haven't eaten any chocolate or changed my diet in any way.
Thanks!
Sara
Hi,
After nine years of severe facial neuropathy, a new doctor tried Methylcobalamin 10,000 mcg/ml injected twice weekly. Within a month, the neuropathy was gone. Considering I had tried everything from neurontin, enbral, methotrexate, you name it, nothing did anything. The only problem is that my skin is now loaded with cystic acne. I have never in my life had acne, let alone cysts. Every day, a new one appears. They are deep and painful. I now know that other people have had the same thing occur with methylocobalamin, even though my doctor claims that the two are unrelated. I know he is wrong. I worry that if I discontinue B12 shots, the neuropathy will return. I also worry that my face will be scarred if I continue. Is there another form of B12 the cures neuropathy that doesn't cause acne? Is there anything I can do now to heal the cysts on my face.
Also, the cysts have spread to the upper back region as well.

Best
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Old 07-13-2007, 02:49 PM #8
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If it is due to the B12, it is probably because another nutrient is lacking. And if that is the case, the body is attempted to repair but doesn't have all of the tools. One possibility is vitamin E. I would make sure all nutrients are covered sensibly, multi, B complex, good E with gamma type, etc.

And of course anyone who is getting shots is likely to be getting cyanocobalamin. Since almost everyone, even with severe malabsorption of B12, does as well or better on daily doses of at least 1000 mcg, I would go with the oral methylcobalamin.

rose
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Old 07-13-2007, 04:33 PM #9
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Lightbulb essential fatty acids...

May help this. Flax oil, evening primrose and fish oil.

Other nutrients that help acne are folic acid and zinc.
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These forums are for mutual support and information sharing only. The forums are not a substitute for medical advice, diagnosis or treatment provided by a qualified health care provider. Always consult your doctor before trying anything you read here.
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Old 10-17-2009, 11:24 PM #10
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Default b12 and acne

Quote:
Originally Posted by OnThe Road Back View Post
Hi all:
I'm currently receiving B12 shots to address a diagnosed deficiency. Since I began the shots a few months ago, I noticed my skin breaking out like a teenager. Has anyone else had this happen or heard of it?
By the way, I haven't eaten any chocolate or changed my diet in any way.
Thanks!
Sara
i started b12 shots and got a rash type acne on my face too!
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