Quote:
Originally Posted by Mark in Idaho
I don't think this concept will make a difference. The primary problem is proximity to the time of injury. Many who suffer a concussion do not experience symptoms that cause enough concern to seek these treatments within the effective time.
There are a number of treatments that show benefit in reducing concussion symptoms but the effective window for administering them is too limiting.
High dose fish oil has shown promise when administered early.
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Of course - early treatment results in the best results.
Isn't most of the damage done by Glutamate? From what I read, a concussion makes all the pre-synaptic neurons dump their neurotransmitters into the synapses, and that specifically leads to an accumulation of Glutamate in certain synapses - this Glutamate later increases calcium ion influx into the neurons, which causes over-excitation that eventually leads to neuron death. Am I right in this, or there are more mechanisms for damage after a TBI?
While I understand that neuron death is responsible for a certain part of the damage done after a TBI, it is said that damage to the axons (connections between neurons) is actually worse and that is what causes most damage, and axonal damage is actually reversible in many cases, if I'm not wrong.
So, while early treatment leads to the best results, can't a treatment given later also aid the brain in healing? The brain keeps healing for months/years after the initial injury, which makes me think that we can administer low doses of neurotoxins to activate repair mechanisms that help the brain recover from the consequences of the neurotoxicity after a TBI.
I know using neurotoxins to heal damage sounds very weird, but read about Hormesis - it's fascinating and that's why I think low doses of neurotoxins can aid in the healing process.