Of course - early treatment results in the best results.

Isn't most of the damage done by Glutamate? From what I read, a concussion makes all the pre-synaptic neurons dump their neurotransmitters into the synapses, and that specifically leads to an accumulation of Glutamate in certain synapses - this Glutamate later increases calcium ion influx into the neurons, which causes over-excitation that eventually leads to neuron death. Am I right in this, or there are more mechanisms for damage after a TBI?

While I understand that neuron death is responsible for a certain part of the damage done after a TBI, it is said that damage to the axons (connections between neurons) is actually worse and that is what causes most damage, and axonal damage is actually reversible in many cases, if I'm not wrong.

So, while early treatment leads to the best results, can't a treatment given later also aid the brain in healing? The brain keeps healing for months/years after the initial injury, which makes me think that we can administer low doses of neurotoxins to activate repair mechanisms that help the brain recover from the consequences of the neurotoxicity after a TBI.

I know using neurotoxins to heal damage sounds very weird, but read about Hormesis - it's fascinating and that's why I think low doses of neurotoxins can aid in the healing process.

You are mixing up two different mechanisms of action. Slowing or reducing damage vs effecting healing of that damage.

The early administration of the substance prevents or slows the cascade of damage. But, if that cascade of damage is not slowed, then that damage spreads and the injury is more intense.

You mention a lot of technical details. One of the concerns you missed is damage to the glymph system. Like the myelin sheath, the glymph system needs to heal. It clears the toxins just like the lymph system does in the rest of the body. It is thought to be slow to heal just like the myelin sheath.

That slow healing would suggest a reason for our brains being so hyper sensitive to stress.