Quote:
Originally Posted by mrsD
There is a paper showing a reduced rate of ACE side effects, with Atacand (which is an ARB, ACE receptor blocker).
http://www.ncbi.nlm.nih.gov/pubmed/12222554
So people who react strongly to elevated bradykinin need to be vigilant if this drug is used after a reaction to ACE inhibitors.
This article is interesting too:
http://www.jneurosci.org/content/25/35/7986.full
The ACE drugs are derived from snake venom. They have a wide range of effects on tissue. Mostly swelling, fluid retention, and lowered blood pressure and increased pain due to NMDA receptor activity.
This link shows the chemical cascade of elevated bradykinin:
ttps://www.firazyr.com/hcp/about-hereditary-angioedema/bradykinin
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I had a dry cough on Ramipril so was switched to ARB called Losartan (aware names might be different in the UK) and I don't think I've had any problems on it although I take on board what you are saying. There is a train of thought that says that BP meds are pointless because real hypertension is relatively rare and getting to the cause is more important. I've read about this recently on Thyroid UK HealthUnlocked.
The thing is that my BP was only borderline high but both my parents dropped dead suddenly from Atherosclerosis relatively young and I'm borderline for this too. Also my optician was surprised to see a flame haemorrhage close to my optic nerve and this usually occurs only with diabetes or hypertension so I felt it would be worth trying to get it under control because having a connective tissue disease increases cardiovascular and stroke risk by 40%.
Also I've been monitored and this is how blood in pee was discovered so it's helped me to keep being investigated for Lupus and Sjogren's despite my negative antibodies for both. I do everything I can fir myself with diet and exercise but still my ESR and CRP are too high so I feel hypertension isn't good. I've never had any drops in BP yet though.