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Old 12-29-2015, 04:01 PM #4
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mrsD mrsD is offline
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mrsD mrsD is offline
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Join Date: Aug 2006
Location: Great Lakes
Posts: 33,508
15 yr Member
Lightbulb

There is a paper showing a reduced rate of ACE side effects, with Atacand (which is an ARB, ACE receptor blocker).

http://www.ncbi.nlm.nih.gov/pubmed/12222554

So people who react strongly to elevated bradykinin need to be vigilant if this drug is used after a reaction to ACE inhibitors.

This article is interesting too:
http://www.jneurosci.org/content/25/35/7986.full

The ACE drugs are derived from snake venom. They have a wide range of effects on tissue. Mostly swelling, fluid retention, and lowered blood pressure and increased pain due to NMDA receptor activity.

This link shows the chemical cascade of elevated bradykinin:
ttps://www.firazyr.com/hcp/about-hereditary-angioedema/bradykinin
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