I have had to move my doses closer together due to wearing off and having very uncomfortable dystonia. I take Sinemet every 3 hours along with requip and amantadine. I have tried the CR going to bed, Dr. thought it might get me through the night. I found it upset my stomach and didn't help much to get me through the night. I can see using it as well as the fast acting Sinemet but I wouldn't want to use it alone. The yellow zingers work best for me.