article to consider:


Barres and Smith's in vitro findings of importance of brain cholesterol (recalling that fat soluble statins cross the BBB) synopsis: www.sciencemag.org
Neurons need cholesterol secreted by glial cells to form and maintain functional synapses. In addition to synaptogenesis, cholesterol is probably responsible for production and transport of vesicles necessary for neurotransmission. If one accepts the concept of neuronal plasticity in the adult brain, then deliberately
suppressing cholesterol metabolism in the brain seems more than questionable.