the only way to find out its not working and or working is to stop taking it, I have been on it for 3 yrs and have had 3 new lesions, even Nero the neuro hemmed and hawwed at me staying on it, he wants to give it some more time with the LDN, so i am a lab rat for ~10 more months, I honestly can not tell you if it is working or not for me, and I dont care for being in suspended animation, its more of a me me me thingy here I dont like it had two bad reactions and one really freaky one, they think I might of hit a nerve injecting, paralyzed myself from hips down for almost 40 minutes, but the other two reactions, were those rarely seen ones where your heart races you feel like your having a major kicker,