Do you think he is losing weight mostly because of the mouth sores, or a cumulative of everything?
Are they looking at rare diseases? or combination of diseases?
I am guessing they checked for Lyme & Chronic fatigue syndrome??
I know a rare disease called Pemphigus Vulgaris will cause mouth sores and cause severe weight loss. It is autoimmune , but rare.
Just mentioning it as I knew someone who had it-
info-
http://www.google.com/search?q=Pemph...ient=firefox-a
Have you considered Homeopathic/Naturopathic dr?
If the MDs can't figure it out maybe try an expert in alternative care?
Have any special mouth rinses for the sores been tried??