I take 400 mg of SAM-e daily. Typically before I go to bed on a nearly empty stomach.

I had a torn ACL 3 years ago. Had surgery, but arthritis crept in. Also, developed a very small tear in the meniscus on the same knee.

The SAM-e has really helped take away the pain and stiffness. I take anti-inflammatories as well ( green tea extract and curcumin) which might be also helping, but that was well after the improvement in my knee from SAM-e.