According to research cited in Science Daily: "The latest research shows that a combination of three factors together are needed to damage the cell. If any are missing the cell remains viable. The three are dopamine itself, alpha-synuclein and calcium channels. Neurons die because calcium channels lead to an increase of dopamine inside the cell; excess dopamine then reacts with alpha-synuclein to form inactive complexes; and then the complexes gum up the cell's ability to dispose of toxic waste that builds up in the cell over time."

Bacalein from Baikal Skullcap also prevents and dissolves alpha-synuclein protein tangles in neurodegenerative diseases such as PD. Perhaps a combo of this and
the CCB isradipine with a calcium binding protein such as apoaequorin (Prevagen) might disrupt this process.