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11-25-2011, 04:04 PM | #1 | |||
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In Remembrance
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At least I haven't found another. Consider this review published just this year-
1. CNS Neurol Disord Drug Targets. 2011 Mar;10(2):184-91. Flavones from root of Scutellaria baicalensis Georgi: drugs of the future in neurodegeneration? Gasiorowski K, Lamer-Zarawska E, Leszek J, Parvathaneni K, Yendluri BB, Błach-Olszewska Z, Aliev G. Department of Basic Medical Sciences, Faculty of Pharmacy, Wroclaw Medical University, 14 Kochanowskiego Str., 51-601Wroclaw, Poland. Flavonoids are natural, plant-derived compounds which exert diverse biological activities, also valuable neuroprotective actions within the brain and currently are intensively studied as agents able to modulate neuronal function and to prevent age-related neurodegeneration. Among them, flavones isolated from Scutellaria baicalensis root exhibit strong neuroprotective effects on the brain and are not toxic in the broad range of tested doses. Their neuroprotective potential has been shown in both oxidative stress-induced and amyloid-beta and alpha-synuclein-induced neuronal death models. Baicalein, the main flavone present in Scutellaria baicalensis root, strongly inhibited aggregation of neuronal amyloidogenic proteins in vitro and induces dissolution of amyloid deposits. It exerts strong antioxidative and anti-inflammatory activities and also exhibits anti-convulsive, anxiolytic, and mild sedative actions. Importantly, baicalein, and also another flavone: oroxylin A, markedly enhanced cognitive and mnestic functions in animal models of aging brains and neurodegeneration. In the preliminary study, wogonin, another flavone from Scutellaria baicalensis root, has been shown to stimulate brain tissue regeneration, inducing differentiation of neuronal precursor cells. This concise review provides the main examples of neuroprotective activities of the flavones and reveals their potential in prevention and therapyof neurodegenerative diseases. PMID: 21222632 [PubMed - indexed for MEDLINE]
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Born in 1953, 1st symptoms and misdiagnosed as essential tremor in 1992. Dx with PD in 2000. Currently (2011) taking 200/50 Sinemet CR 8 times a day + 10/100 Sinemet 3 times a day. Functional 90% of waking day but fragile. Failure at exercise but still trying. Constantly experimenting. Beta blocker and ACE inhibitor at present. Currently (01/2013) taking ldopa/carbadopa 200/50 CR six times a day + 10/100 form 3 times daily. Functional 90% of day. Update 04/2013: L/C 200/50 8x; Beta Blocker; ACE Inhib; Ginger; Turmeric; Creatine; Magnesium; Potassium. Doing well. |
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11-25-2011, 09:49 PM | #2 | |||
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According to research cited in Science Daily: "The latest research shows that a combination of three factors together are needed to damage the cell. If any are missing the cell remains viable. The three are dopamine itself, alpha-synuclein and calcium channels. Neurons die because calcium channels lead to an increase of dopamine inside the cell; excess dopamine then reacts with alpha-synuclein to form inactive complexes; and then the complexes gum up the cell's ability to dispose of toxic waste that builds up in the cell over time."
Bacalein from Baikal Skullcap also prevents and dissolves alpha-synuclein protein tangles in neurodegenerative diseases such as PD. Perhaps a combo of this and the CCB isradipine with a calcium binding protein such as apoaequorin (Prevagen) might disrupt this process. |
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"Thanks for this!" says: |
11-29-2011, 09:04 PM | #3 | ||
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Quote:
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11-30-2011, 02:24 AM | #4 | |||
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Thanks for the kind words. I am not familiar with the properties of those
Chinese herbs but I will check with my TCM doctor and see what she thinks. |
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11-30-2011, 09:24 PM | #5 | ||
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We were alerted to the actions of Gou Teng/Gambir/Uncaria Rhynchophylla by an article in New Scientist 17th of June 2011, "Chinese Medicine Offers New Parkinson's Treatments" in which Li Min, a tradition Chinese doctor at Hong Kong Baptist University is interviewed about a Parkinson's trial in which gou teng was used as part of a formula. She talks about its actions on alpha-synuclein. Rhynchophylline, found in Uncaria Rhynchophylla, is described in Wikipedia as a "calcium channel blocker" with some references, which is why we thought of it for your triple therapy idea. Perhaps we shouldn't have mentioned Lycium Chinense in this context. We were thinking of it because we were researching Gou Teng and came across an article titled "Inhibition of monoamine oxidase B (MAO-B) by Chinese Herbal Medicines", 2003, (see Pubmed). In this article both Uncaria Rhyncophylla and Lycium Chinense performed well. Thanks again, Paul & Sarah |
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