Thread: CMT and Statins
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Old 10-22-2012, 10:38 AM
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mrsD mrsD is offline
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mrsD mrsD is offline
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Join Date: Aug 2006
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Lightbulb

Okay, thank you...that is helpful.

Red Yeast Rice contains statin type molecules. Depending on the brand it is spotty in effect. But all of them have lovastatin in some concentration, as the rice is a source of it naturally.
http://en.wikipedia.org/wiki/Lovastatin

I am unsure if you are receiving therefore enough to make a difference.

Now, can you tell me why you are taking the iron? Did the doctor tell you to? The reason I ask is that iron is not recommended unless your blood work says so. Anemia or low hematocrit. Men's vitamins do not typically contain iron, because it can accumulate and cause damage to the heart.

Chronic use of Prilosec... has been shown to affect these nutrients:
B12
folic acid
calcium
magnesium
zinc
iron absorption

Your B12 is still good, but I'd keep an eye on it, because eventually you will use up your stored B12 from the liver (up to 5yrs worth) and then become low. B12 is broken out of protein food, by acid and by removing that, the B12 cannot be absorbed any more. Proton pump inhibitors also now have the warning about osteoporosis risk because they block calcium absorption too.

Ace inhibitors for blood pressure taken for long periods also impact zinc, and so does the Prilosec.

Low magnesium can lead to many issues with nerves. So I'd consider using a good magnesium supplement like SlowMag (available at WalMart) twice a day.
Look at your multivitamin and check if it has zinc. That may be all you need at this point. If you have bleeding gums or sores that don't heal fast, or losing more hair than normal consider a zinc supplement. OptiZinc is the nicest with few GI side effects.

Taking that neuropathy formula... you should do this on an empty stomach, so the B12 and ALA will be absorbed properly.
If you don't do this, you may lose that value for those nutrients.

I am going to digress a minute... about the rampiril:
This ACE inhibitor is the only one in that family that can cause
liver damage. So I hope you are getting liver tests regularly with your check ups.
http://en.wikipedia.org/wiki/Ramipril
and
http://www.ncbi.nlm.nih.gov/pubmed/14567716

As a suggestion lisinopril, is much easier to tolerate in the body, and is not metabolized by the liver at all. So consider this as a possible intervention for you at another time. I, myself, switched to lisinopril years ago after learning about how much better it can be than some of the other drugs in that family.

Now, chronic use of Xanax or other benzodiazepines can lead to more symptoms of PN... this is because tolerance occurs quickly and the drug wears off (and Xanax is fast acting anyway) and when it does, the tingling etc starts as part of what is called a mini withdrawal. It may help you fall asleep quickly but by morning you will start to have the withdrawal, and hence peripheral symptoms. If you can discuss changing your sleep medication to melatonin, or Ambien or any non-benzo drug, you may see some improvement there. Xanax must be tapered off carefully if you have used it for a long time. If you choose to do this, with your doctor's approval, you may see increased PN symptoms for a while. (that is the withdrawal symptom).
Benzos have effects on nerves...they are used sometimes as an anticonvulsant is used in seizure patients. Often they are given for that reason. Withdrawal therefore is going to show excitation of nerves to some degree. So consider this.

Withdrawal and "mini" withdrawal is explained here:
http://www.bcnc.org.uk/howtowithdraw.htm
Quote:
Switching to a long-acting Benzodiazepine. With certain short-acting benzodiazepines it is not possible to achieve a smooth decline in blood and tissue concentrations. These drugs are eliminated fairly rapidly with the result that concentrations fluctuate with peaks and troughs between each dose. It is necessary to take the tablets several times a day and many people experience a "mini-withdrawal", sometimes a craving, between each dose. For people withdrawing from these potent, short-acting benzodiazepines it is advisable to switch to a long-acting slowly metabolised benzodiazepine such as Diazepam. The switch over process needs to be carried out gradually.
While your use is not heavy, or problematic in the habituation sense, your body is still in a mini-withdrawal just a few hours after you take that Xanax. Your nerves are telling you so, I believe. The gabapentin is possibly masking some of this, and it too is an anticonvulsant. (dampens nerves).

Benzos are good for the short term, but long term one can get into a negative cycle, with them wearing off, and causing side effects. Xanax is the fasting acting one so the most noticeable, in this regard. So you may have to think about this and discuss a change in bedtime sleep induction that will not be a benzodiazepine.

That is all I can see for now. It is more than I thought would be a potential problem for you.

Here is a site that explains drug nutrient depletions. People taking chronic meds, can benefit from understanding how RX drugs impact our chemistry in ways not well attended to by doctors:
http://www.chiro.org/nutrition/ABSTR...orticosteroids

I have two reference books on this subject that I consult, which are more complete than the online lists.
The Side Effects Bible by Dr. Vagnini MD
And
Drug Induced Nutrient Depletion Handbook by
Ross Pelton RPH, PhD, CCN and James LaValle, RPH, DHM, NMD, CCN
Ernest Hawkins RPH, MS
Daniel Drinsky, RPH, MS
2nd Ed. (out of print at this time).



Quote:
Originally Posted by RonJ View Post
OK, here are the meds I take:Ramipril-5mg. twice a day; Tamsulosin-0.4mg. once a day;Simvastatin-20mg. once a day( I have discontinued this) and now take Red Rice Yeast instead);Omeprazole-20mg. once a day; Alprazolam-1mg. at night to help with sleep; Plavix-75mg. once a day; Gabapentin-300mg. at night for foot pain.

I also taker the following ; Resveratrol-500mg once a day; Iron-65 mg. once a day; Glucosamine-Chondroitin-1,500 mg once a day, and a multi-vitamin/mineral tablet once a day.

During my initial visit to my intern this may, he did the following blood tests: HGB AIC-result 5.0;TSH-Result 1.1671;Anti-Nuclear Antibody(ANA)-Result <1:40NEG;Ultra Sensitive CRP-Result0.29;ESR-Result 8;Vitamin B12-Result 821.

During my visit to the Neurologist in last August, she did additional blood work. She told me it was all negative. I am in the process of getting a copy of the results.

I am also now taking two capsules twice a day of the Neuropathy Support Formula, which I plan on trying for 3 or 4 months,and Ubiquinol QH Absorb, reduced form Co-Q10, 100mg. capsule twice a day.

If you need anything further, please let me know.

I will very much appreciate your further comments on my condition.

Thank you.
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"Thanks for this!" says:
RonJ (10-22-2012), Sallysblooms (10-22-2012)