OK, here are the meds I take:Ramipril-5mg. twice a day; Tamsulosin-0.4mg. once a day;Simvastatin-20mg. once a day( I have discontinued this) and now take Red Rice Yeast instead);Omeprazole-20mg. once a day; Alprazolam-1mg. at night to help with sleep; Plavix-75mg. once a day; Gabapentin-300mg. at night for foot pain.

I also taker the following ; Resveratrol-500mg once a day; Iron-65 mg. once a day; Glucosamine-Chondroitin-1,500 mg once a day, and a multi-vitamin/mineral tablet once a day.

During my initial visit to my intern this may, he did the following blood tests: HGB AIC-result 5.0;TSH-Result 1.1671;Anti-Nuclear Antibody(ANA)-Result <1:40NEG;Ultra Sensitive CRP-Result0.29;ESR-Result 8;Vitamin B12-Result 821.

During my visit to the Neurologist in last August, she did additional blood work. She told me it was all negative. I am in the process of getting a copy of the results.

I am also now taking two capsules twice a day of the Neuropathy Support Formula, which I plan on trying for 3 or 4 months,and Ubiquinol QH Absorb, reduced form Co-Q10, 100mg. capsule twice a day.

If you need anything further, please let me know.

I will very much appreciate your further comments on my condition.

Thank you.

Okay, thank you...that is helpful.

Red Yeast Rice contains statin type molecules. Depending on the brand it is spotty in effect. But all of them have lovastatin in some concentration, as the rice is a source of it naturally.
http://en.wikipedia.org/wiki/Lovastatin

I am unsure if you are receiving therefore enough to make a difference.

Now, can you tell me why you are taking the iron? Did the doctor tell you to? The reason I ask is that iron is not recommended unless your blood work says so. Anemia or low hematocrit. Men's vitamins do not typically contain iron, because it can accumulate and cause damage to the heart.

Chronic use of Prilosec... has been shown to affect these nutrients:
B12
folic acid
calcium
magnesium
zinc
iron absorption

Your B12 is still good, but I'd keep an eye on it, because eventually you will use up your stored B12 from the liver (up to 5yrs worth) and then become low. B12 is broken out of protein food, by acid and by removing that, the B12 cannot be absorbed any more. Proton pump inhibitors also now have the warning about osteoporosis risk because they block calcium absorption too.

Ace inhibitors for blood pressure taken for long periods also impact zinc, and so does the Prilosec.

Low magnesium can lead to many issues with nerves. So I'd consider using a good magnesium supplement like SlowMag (available at WalMart) twice a day.
Look at your multivitamin and check if it has zinc. That may be all you need at this point. If you have bleeding gums or sores that don't heal fast, or losing more hair than normal consider a zinc supplement. OptiZinc is the nicest with few GI side effects.

Taking that neuropathy formula... you should do this on an empty stomach, so the B12 and ALA will be absorbed properly.
If you don't do this, you may lose that value for those nutrients.

I am going to digress a minute... about the rampiril:
This ACE inhibitor is the only one in that family that can cause
liver damage. So I hope you are getting liver tests regularly with your check ups.
http://en.wikipedia.org/wiki/Ramipril
and
http://www.ncbi.nlm.nih.gov/pubmed/14567716

As a suggestion lisinopril, is much easier to tolerate in the body, and is not metabolized by the liver at all. So consider this as a possible intervention for you at another time. I, myself, switched to lisinopril years ago after learning about how much better it can be than some of the other drugs in that family.

Now, chronic use of Xanax or other benzodiazepines can lead to more symptoms of PN... this is because tolerance occurs quickly and the drug wears off (and Xanax is fast acting anyway) and when it does, the tingling etc starts as part of what is called a mini withdrawal. It may help you fall asleep quickly but by morning you will start to have the withdrawal, and hence peripheral symptoms. If you can discuss changing your sleep medication to melatonin, or Ambien or any non-benzo drug, you may see some improvement there. Xanax must be tapered off carefully if you have used it for a long time. If you choose to do this, with your doctor's approval, you may see increased PN symptoms for a while. (that is the withdrawal symptom).
Benzos have effects on nerves...they are used sometimes as an anticonvulsant is used in seizure patients. Often they are given for that reason. Withdrawal therefore is going to show excitation of nerves to some degree. So consider this.

Withdrawal and "mini" withdrawal is explained here:
http://www.bcnc.org.uk/howtowithdraw.htm
While your use is not heavy, or problematic in the habituation sense, your body is still in a mini-withdrawal just a few hours after you take that Xanax. Your nerves are telling you so, I believe. The gabapentin is possibly masking some of this, and it too is an anticonvulsant. (dampens nerves).

Benzos are good for the short term, but long term one can get into a negative cycle, with them wearing off, and causing side effects. Xanax is the fasting acting one so the most noticeable, in this regard. So you may have to think about this and discuss a change in bedtime sleep induction that will not be a benzodiazepine.

That is all I can see for now. It is more than I thought would be a potential problem for you.

Here is a site that explains drug nutrient depletions. People taking chronic meds, can benefit from understanding how RX drugs impact our chemistry in ways not well attended to by doctors:
http://www.chiro.org/nutrition/ABSTR...orticosteroids

I have two reference books on this subject that I consult, which are more complete than the online lists.
The Side Effects Bible by Dr. Vagnini MD
And
Drug Induced Nutrient Depletion Handbook by
Ross Pelton RPH, PhD, CCN and James LaValle, RPH, DHM, NMD, CCN
Ernest Hawkins RPH, MS
Daniel Drinsky, RPH, MS
2nd Ed. (out of print at this time).

I also forgot to add:

As you take the CoQ-10 supplement, you may find that your current dose of blood pressure medication is too strong.

Ideally taking your own pressures at home will reveal this.
But if you don't have a cuff, then report and dizziness on standing or feelings of faintness etc to your doctor.

When CoQ-10 is low blood pressure can go up. As this is fixed,
the pressure may improve and you may need a dosage adjustment of your medication.

Too bad the 2nd book is out of print. I will have to get the other book.

Mrs D, thank you for your very helpful response. If I may, I have a few questions for clarification regarding your observations.

First, as to the Red Yeast Rice. Are you suggesting that I increase the dosage, or that I stay on the statin, or what?

I am taking the iron because I have a long history of anemia, but it is pretty much optional as far as my doctor is concerned. I am monitored twice a year with blood work so I don't really have a worry about it or the ace inhibitor.

I will take your advice and start taking the magnesium supplement you recommended.

Your observations about Xanax is interesting. No one, including my doctors, have mentioned that. If it has the potential of increasing my PN symptoms then I will discuss with my doctor getting off it.

My multivitamin has zinc, but I have noticed hair loss on my legs, and sores not healing as quickly as they should, so I will also start the zinc supplement, as well.

I do know about taking the Neuropathy Support Fomrula on an empty stomach.

Lastly, as to your caution about watching my blood pressure, I do have a cuff, and although I do monitor my pressure periodically, I will start to do so more frequently.

Thanks again. And, any additional advice you may have to help manage or resolve my PN will, of course, be most welcome.

Well, as far as the Red Yeast rice goes, it has the potential to cause the same effects as any statin, since it has statins in it.

So taking it is confusing. If it is weak enough it won't matter either for your PN or cholesterol. If it is a strong brand, you will still be taking a "statin" so you gain nothing in your trial to see if stopping statins will help you. In other words it is "confounding".

Many doctors only know superficial things about drugs. Things from the inserts which are limited, and very little post marketing information. They learn from drug reps mostly, and Xanax is no longer detailed.

I am sending you a link to explain more in detail about how the benzos can cause symptoms similar to PN.

Hair loss on the legs often comes with aging, and can also be connected to PN. Also from low thyroid. I've lost all the hair on my arms and thighs, but still have a little on my legs. I attribute this to my low thyroid for so many years.

The benzo problems have to due with causing hyperactive nerve responses over time (as the drugs wear off). It is subtle and only doctors familiar with addiction and withdrawal may understand it.

The effects of the CoQ-10 will not be immediate, but possibly by the first month of use is over.

Ron, if you decide to stop using your Xanax at bedtime, you ideally should taper off. I would do so slowly... because your body is used to this dose, esp if you have been on it a long time.

Discuss this with your doctor. But realize that some doctors may refuse a taper, or do one too fast.

Please post here after you discuss this with your doctor.
And also consult that Benzo site I gave you in the PM I sent.

I read on another site that someone who stated that he had CMT claims to have "cured" it with large does of vitamins E, C and CO-Q1O,

What do you folks think?

Not true. They have and are having trials all over the world on Ascorbic Acid (Vitamin C. Nothing has worked as far as that goes. We all would be cured if that were true. There is no treatment/cure at the present time for any type of CMT.

You can have side effects from too much Vitamin C. Those trials are very controlled and some people could not tolerate it at all.

Well, we don't know the details of what people often post on the net.

There are many variants of CMT. In the recent past it looked promising that high dose Vit C could help, but then when the trials happened, it was disappointing.

http://lpi.oregonstate.edu/ss06/charcotmarietooth.html
and
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3154498/

Rodent studies don't always translate to humans. I recently saw a figure of about 60% only may apply to humans after rodent study successes.

There is no harm in trying them, however that I know of. You will want
to make sure your kidneys are working normally, however.

If you do the E, get natural and one with all the forms combined, including gamma. Natural ones typically end in --OL (tocoferOL)
and not --YL