Hey Mrs. D,
Thanks for the reply....
Adding the oral methyl or adeno versions is easy enough...the injections I've been offered are the normal cyno b12. Not really sure what to go with...wish I could find moe info on how to interpret that b12 binding test...my doc ordered through Quest.
if I am correct, i.e., the binding test results mean that although I am ingesting B12, not much of it is being bound and used properly, I am wondering how one would overcome this issue...its would appear, even if I added the oral versions you mentioned, they still wouldn't be bound and utilized? or maybe its just means I need to get my levels super high, so that even though only a small % is being bound, it still equates to a normal total amount of B12 being used.
In regards to adding the methyl folate, I understand it is important to correct the B12 issue prior, but in my case, where there isn't an actual low level of serum b12, how do I know when it is corrected and to add the folate? my folate levels have always been in the normal range.
Quote:
Originally Posted by mrsD
This explains some:
http://mthfr.net/what-is-mthfr/2011/11/04/
I think you need methyl forms of both folate and B12.
That would be Metafolin (methylfolate) and methylcobalamin.
I cannot find an answer online regarding low binding capacity (transcobalamin) levels. This is a relatively new concept and is a new test in US.
One site I looked at suggested using hydroxocobalamin instead of cyano or methyl, as injections. If you go the injection route, you could try that. The suggestion is to flood the serum and bypass the transcobalamin deficiency... Perhaps the injections often (not once a month) would have an effect.
There is another B12 called adenosylB12... you could try that orally. Take on an empty stomach;
This is one affordable source:
http://www.vitacost.com/nutricology-...Fe8WMgod4U8AUA
Unless your injections are frequent, I think daily oral would be a better route.
Once you get your B12 treated you can do the folic acid as methylfolate. It appears you have some mutation there that hinders methylation. So regular folic acid would not be fruitful for you.(it is not active and requires methylation to work). |