It takes time for SAMe to work. You have to rebuild tissue lost after all. I started at 200mg a day (it was very expensive then), and slowly raised to 600mg a day.

Now I just take 400mg a day. I've tried to quit it, but my pain keeps coming back without it. So I am back on again (3rd time).

It is best to build slowly up in dose IMO. The chemistry has to be rekindled for healing if it has stopped.

People with poor acid in the stomach may dissolve the enteric coating prematurely before the tablet can get to the intestine.
I think that is where the nausea comes from...the tablet dissolving in the stomach where it does not belong.

It is best to take it before eating...that way it will move along quickly and not dissolve in the stomach. In Europe they had only injectable form, you know.

So you've used it for years? I probably stayed with it a couple months each time, maybe...it's pricey and not knowing HOW LONG to stick with it...makes one stop if not feeling any results. I guess. I'm back on glucosamine, I had taken it off and on for years but this time I'm staying with it. Talking about how long to stay with "something", my grape seed ex is a true testiment to this theory....20 yrs soon. But I did get positive results in a week or so in the beginning which told me something...stay with it!

I started it the first year my son started college....it was on sale on an endcap at WalMart's. I was there buying stuff for the dormitory --shower stuff toothpaste etc. It was about $15.00 for 10 tablets of 200mg. (my son will be 34 this month and was 18 at the time). I had just had my MRI on the knee too. It showed synovitis. After a month using it I knew I would continue. It gave me lots of energy which during the post menopausal times I really needed for work.

I managed the pain standing at work with my neodymium magnets.

I took the SAMe for over a decade every day. I stopped about 3 yrs ago thinking I didn't need it anymore. But I was wrong. The process creating the pain started up again. I had thought I had rebuilt my knee. But I was foolish... the process is going to continue forever to destroy it. So I am back on it each morning.
And already in a week I am seeing small improvements (not needing my brace, etc). This is much faster than before.

SAMe is a slow rebuilding supplement. It is not quick like drugs, for pain. But it is one of the few (if any) things with medical research behind it.

Caroline have you seen info on Apple Cider vinegar -with the mother?

It is another great thing for overall health and lots of other uses around the home..
https://www.google.com/search?q=Appl...negar+benefits
https://www.google.com/search?q=Appl...fits+arthritis


I take it off & on for low acid /overall health, I need to be more regular with it...

Jo, I've used ACV off and on for years. Am off it now...Just went thru a quart recently of braggs...don't know if it helped me ever or not.

My knee OA has been going on since I was 57 and I'm 77 this year...so 20 yrs. The hip replacement really messed my body up so badly that caused my right side to be shorter, hence the knee got worse, which caused the foot/ankle to advance with OA. At 57 is when I first went to a doc about it, he was a sport med doc. It was creeking, aka crepitus. So I've gone for almost 20 yrs with this knee as it's the hip job that really did me in with whole body alignment. I wear heel lifts now but it was almost 2 yrs before I found out how much shorter my leg was from surgery.

So I don't know what I'll do next, if I didn't have to walk much, I'm OK, just got back from market and was pretty good when I left and now I'm limping. Then I deal with all this nerve damage above the knee. I could scream and sometimes I do.

Still have Prolozone and PRP in my back pocket to do, but again it's the shorter overall right side of body.