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- Bipolar Disorder (https://www.neurotalk.org/bipolar-disorder/)

- - Latuda (https://www.neurotalk.org/bipolar-disorder/191816-latuda.html)

I am so glad that the medication is helping. BF:hug::hug::hug:

Thanks Bizi and Waves. After trying so many med combos I am super happy to something that seems to work, doesn't cause weight gain, and the rest of the side effected are tolerable.

I bought my own DSM5so. I can read up. On my diagnosis' that may sound odd to someone who doesn't have this.

Thanks,

Quote:

The newly approved 120 mg and 160 mg lurasidone dose is administered once daily, preferably in the evening with at least 350 calories of food in order to optimize bioavailability.4 Lurasidone is primarily metabolized in the liver through the CYP3A4 enzyme system, and coadministration with drugs that are strong inhibitors of CYP3A4 (e.g., ketoconazole) or strong inducers (e.g., rifampin) is contraindicated.4

Also here:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3171824/

Quote:

Peak serum concentrations (Cmax) and absorption occur in approximately one to three hours. From 9% to 19% of the administered dose is absorbed. Following administration of a 40-mg dose, the mean apparent volume of distribution is 6,173 (17.2) L. The drug is highly bound (approximately 99%) to serum proteins. According to the manufacturer, patients were instructed to take lurasidone with food (consisting of a minimum of 350 calories) in a clinical trial. The Cmax and area-under-the-curve (AUC) concentration of lurasidone, when consumed with food, were about three times and two times, respectively, the levels observed under fasting conditions.15

I used to get copies of the DSM. When my nurse friend would get a new DSM, she would give me her old copy. I gained a lot by looking through the manual, not only for my meds but other meds as well.

Mari

that is so great!
bobby

I figured it is close enough to dinner. I usually have dinner no later than 6 and take my Meds around 8. Do you think that is sufficient? Thanks a bunch.

Quote:

Originally Posted by Mari (Post 1009332)

Hi, TBI/PTSD

That is good that Latuda is helping you.
Are you taking it with 350 calories of food?
Most meds are absorbed better with food.
Latuda has it listed:

http://cpnp.org/resource/mhc/2012/12...-dos-and-donts

Also here:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3171824/

I used to get copies of the DSM. When my nurse friend would get a new DSM, she would give me her old copy. I gained a lot by looking through the manual, not only for my meds but other meds as well.

Mari

Quote:

Originally Posted by TBI/PTSD (Post 1009566)

I figured it is close enough to dinner. I usually have dinner no later than 6 and take my Meds around 8. Do you think that is sufficient? Thanks a bunch.

Hi,

Check with a pharmacist or the doc.
My guess is that not all of the medication is getting absorbed if it is taken two hours away from a meal of 350 calories.

Essentially you are getting a lower dose than you were prescribed.
If it is working for you, then O.K.

Mari

no I think you need to take your med right after you eat then take your other meds at 8. sorry just my opinion.
bizi

Thanks all! I will take heed. I certainly feel like I need more Mari and Bizi so I will give it a whirl w dinner. Thanks for your support.

Quote:

Originally Posted by TBI/PTSD (Post 1010522)

Thanks all! I will take heed. I certainly feel like I need more Mari and Bizi so I will give it a whirl w dinner. Thanks for your support.

Good luck with that, TBI.

It could work for you.
After four days of of change you might notice improvement ( or anything really).

M

Hi,

Just stopping in to wish you well. :)

waves