I have tried Risperidone, Seroquil, lithium, ambilify, and some others, I can't remember. My doc has been with me since the beginning of this new phase of my life and he is wonderful. He is a Forensic Psychiatrist and probably the most brilliant man I have ever met. The best thing about him is that he really listens to me.
I thought all was well w the Latuda but yesterday I was very anxious and verrrrrryyyy angry. Friday will be a week on 20mg of Latuda at which time I will increase to 40 mg.

I really appreciate you taking the time to reply.

Hi TBI/PTSD Try not to worry about the anxiety,and anger at this time. In my experience of over forty years of mental health challenges,these emotions can happen over a period of time no matter what type of medication your on,or changing.

It can really be confusing,and frightening. I know. I'm so sorry. Hang in there,and you will find out in time. If you feel a need,by all means call your doctor. BF

Hi again TBI/PTSD,

Your doctor sounds wonderful! It is so important to have someone who listens!

Wow, you have tried quite a few different drugs. I sure hope this one works out for you. I've tried several too - the antipsychotic (AP) that worked best for me was Zyprexa, but I couldn't handle that because of the weight gain. My current mood stabilizer is Depakote but that works mostly to prevent mania.

Hopefully the anger and anxiety from yesterday are just a bump in the road. In case you are wondering, it is highly unlikely that the Latuda caused those sx. It's likely that that you are still not quite leveled out. From your post, the Latuda does seem to have helped a little, so far. That is good.

Some APs are only effective on activation sx in higher dosage ranges. If that is the case with Latuda, there is lots of room for improvement here, as long as you tolerate it well. Let's keep our fingers crossed.

I wish you well with this new med!

waves

Just a note about a FOOD-DRUG interaction:

It is advisable to avoid grapefruit juice and grapefruit while on Latuda. Grapefruit juice will raise the blood-levels of the drug (via CYP3A4 inhibition). Now, I don't honestly know whether the interaction would bring Latuda to toxic levels (depends on drug toxicity), but an increase in adverse reactions might still be problematic. A simple example might be excessive sedation.

Your doc may have already told you about this interaction, but I figured I'd mention it, since I didn't see it in the prescribing information. The enzyme pathway responsible for this interaction is very clearly disclosed with some of the drug-drug interactions.

If you want to consume grapefruit juice while on this drug, please consult your doctor. He will be aware of the drug's toxicity, adverse effects etc, in relation to your dosage, so he can advise whether there would be a significant problem for you, or not.

IMHO, it would never be a good idea to consume grapefruit while you are increasing or decreasing Latuda. It will throw a wrench into the gradual level change one is performing at these times.

waves

P.S. St. John's Wort and other herbs can also interact with Latuda, via the CYP3A4 enzyme pathway. Some herbs increase drug concentration, others reduce it. (In the latter case, therapeutic response will also be reduced.) It is important to consult your doctor before taking any herbal "supplement" with Latuda.

Yes. With the medications that we are on,try to avoid grapefruit. Hey Waves. That's a good reminder. BF

Hi, Tbi/PTSD,

Yes, stay for the course and keep hoping for the best.
Having a great doc you can trust helps you get through the bumps in the road.

Mari

Ok, I pulled a rookie move. I wasn't supposed to start tapering the Lamictal until I was on full dose 40 mg Latuda. I saw my doc yesterday. I feel crazy, I know....but I hear people talking to me in my head and I answer them out loud. I am super angry still. I know I am going through a change w the Meds so I am trying to get through it. My parents are out of town, my dear friends that are my dash 2 parents are out of town, so I told my neighbors that they are it if I have trouble, I will call them first.

I see things people are not supposed to see, I am too observant, I am exhausted from taking all the superfluous info in. I check people's license plates to see of they are up to date, I notice things that I shouldn't pay any mind to but I can't let go.

Thanks for the tips on grapefruit juice. I like just about all food/drinks but I do have a hard time w grapefruit juice. I really appreciate you taking the time to check it out. So far I find that I am not hungry. I push a vitamix fruit veggie protein powder smoothie down in the AM but the rest of the meals are a struggle.

I am not sure what the other people like us do without this site, I gain so much from you guys, thanks.

What did your doctor say about your increased symptoms?
This must seem crazy for you.
sounds manic to me or headed there.
I amsorry that you are having these strong emotions, just because you are feeling them doesn't mean you have to act on them.
Try if you can to reel your behavior in. What is a full dose for the new medication?
and when do you expect it to be in your system?
worried....
bizi

My doctor attributes the moods to the stress of changing Meds. I have an appt w him again in a week instead of two. I can't remember what he said about it, unfortunately. I started taking my full dose of 40 mgThur night so this is day one of the first full dose. As far as the Meds getting to my system, I am not sure.

I am trying to stay real busy. Today I ran, went to dr. Appts and went kayaking for three hours. I wanted to relax but I couldn't so I went to the grocery store and cam home and cooked and now heading to bed.

I have made it through another day.

Thanks BIZI

[QUOTE=bizi;1004262]What did your doctor say about your increased symptoms?
This must seem crazy for you.
sounds manic to me or headed there.
I amsorry that you are having these strong emotions, just because you are feeling them doesn't mean you have to act on them.
Try if you can to reel your behavior in. What is a full dose for the new medication?
and when do you expect it to be in your system?
worrie

I bet you are very sore of 3 hours of kayaking! that sounds like a lot if you aren't already used to that level.
try to take it a day at a time. I am hoping that you are sleeping thru the night. so important.
bizi