Horse smell.. LOL.. but hey it works, seriously not joking.

One of the reason behind the top 10% is because they allow sick people to participate in developing the ranges, the ranges are developed not for "healthy" people but for people not dying of disease. Your trying to be healthy.

I realize your adrenals would have a hard time on pain meds.. i have had to increase my hydrocortisone, thanks for the reminder.. argh.. my pooe adrenals have given out , i'd like to get a handle on exactly why?

Adrenal fatigue (or insufficiency) can be caused by chronic pain, other forms of stress, infection, inflammation, environmental toxins, diet (caffeine, carbohydrates) and other factors - not just opioids. It's often found in people with diabetes and thyroid problems.
Google: adrenal fatigue causes

If you suspect some particular reason/trigger, try googling that with adrenal fatigue, and see if a cause/effect connection turns up in the literature.

Doc

So sorry to hear of your story.Im 47 female going thru menopause and had dentures put in 7 months ago. Im suffering from Burning mouth syndrome.I feel like Im dying I cant eat its too painful. You have any ideas? Thank so much

Klonopin in dissolvable form works wonders for BMS, but Klonopin also can become highly addictive and you can build up a tolerance. But living with BMS may be worth taking the drug.
I don’t have BMS myself but I have read a few people with BMS and this was only thing that gave them relief. Remember, its got to be the dissolvable version not the regular pill form.

Are you saying/implying that the BMS is a result of or caused by having had the dentures put in?

I hadn't heard of this condition before, but there seems to be quite a bit of information on the web. My first thought before even looking was that it sounds like something involving the peripheral nervous system, and sure enough...
Another treatment that seems to work for some is Alpha Lipoic Acid (with no addiction/dependence risk).
Many people with Peripheral Neuropathy take a form of this - Stabilized R-Lipoic Acid. When taking this form, only 100 mg is as effective as 600 mg of Alpha Lipoic Acid.

In the event we're spinning our wheels here, it might be helpful to tell us a bit more (start a separate thread for clarity) about what you know about your BMS (primary/secondary, suspected cause(s), tests, things you've already tried, etc.)

Doc

Really 100mg of stabilized ALA? Can you explain? I always thought regular ALA are comprised of components R and S. We don’t absorb the S so half of it is wasted, therefore I have always concluded that you need to take 300mg of ALA-R versus 600mg of ALA.

Are you implying because it’s stabilized, 100mg of stabilized = 300mg ALA-R (non stablized)=600mg ALA?

This is the thread where we all at PN discuss and discover the solubility of the various lipoic acid formulations.

http://neurotalk.psychcentral.com/sh...light=Blaylock

I'm not a chemist or pharmacologist, so I cannot explain the reasons myself. At first, I assumed the same as you, that 300 mg would be what's required, but it's not. The stabilized form had nothing to do with it; 100 mg. of regular RLA works as well as 600 mg of ALA, though some people do take more.

I do recall digging the info out of threads here, and following up on the web, even if I didn't understand it entirely. I'm on my first month of the stabilized form now (had to use up supplies of regular RLA) but I have not personally noted any difference over regular RLA as yet.

I started RLA over a year ago now, and it has been near-miraculous in my case (results may vary considerably). The stuff stopped my burning/pins & needles pain from PN within 48 hrs, and progression of the condition has stopped as well (but I cannot say for certain the RLA is responsible for that - it could be a number of factors).

Doc

To put it simply:

RX drugs go thru an expensive process to make them BIOavailable...meaning they have to be absorbed a certain amount in each person, reliably. This is part of the new drug application evaluated by the FDA. Generics have to match this data within certain statistical limits.

But supplements do not go thru this process unless the maker
chooses to. So therefore, people taking supplements, vitamins and minerals, may not absorb what the label claims is in it.

A case in point is magnesium OXIDE...which for decades was the only supplement of magnesium out there. But it is very poorly absorbed we know now when recent studies compared various salts of magnesium and found OXIDE the worst in this regard. But doctors still prescribe it...unknowing. The NIH website has this information on it now, but of course doctors don't read it.
http://ods.od.nih.gov/factsheets/magnesium/
This is only one example. Other supplements have solubility and BIOavailability issues also. CoQ-10, Lipoic acid, curcumin,
zinc, B12, to name a few. Sometimes it is as easy as taking on an empty stomach, but other times the supplement has to be modified to be absorbed better. R-lipoic is one that when solubilized with sodium, is better absorbed, and hence works better at lower doses. Alpha lipoic therefore has 3 issues.
1) the old racemic mix...is not all useful to the body
2) focusing on R-lipoic sounds good, and is out there...BUT....
3) Sodium RALA (NaRALA) is most soluble in the stomach and hence thought to be the best one we have now. (this one is called STABILIZED on the label.)

Some new technologies are coming for liposomal nano-emulsions of various vitamins and supplements, and we will see more of these soon. Vit C and curcumin are examples available now in liposomal forms to enhance absorption further.
So far they tend to cost more money, but that will probably change as time passes and demand accelerates for them.

And in the future what we say now, will most likely be obsolete.

Would that statistical limit be around 85%? A friend in medicine once told me that generics only have to be 85% as effective as brand-names, which is why some people swear by the brand-names and dis the generics.

Doc