FAQ/Help |
Calendar |
Search |
Today's Posts |
|
Chronic Pain Whatever the cause, support for managing long term or intractable pain. |
Reply |
|
Thread Tools | Display Modes |
03-14-2012, 09:16 AM | #31 | |||
|
||||
Wisest Elder Ever
|
That 85% comes up over and over! It is a mathematical % and
not a comparison %. It has to due with area under the curve, in logarithmic numbers. It does NOT mean 85% of the parent compound per dose. It is on the FDA website. http://www.fda.gov/Drugs/Development.../ucm079068.htm Quote:
But this 85% (mostly in relation to opiates), is a misquote of a concept not well understood by laymen, or doctors. Scroll down to "statistical criteria of bioequivalence"
__________________
All truths are easy to understand once they are discovered; the point is to discover them.-- Galileo Galilei ************************************ . Weezie looking at petunias 8.25.2017 **************************** These forums are for mutual support and information sharing only. The forums are not a substitute for medical advice, diagnosis or treatment provided by a qualified health care provider. Always consult your doctor before trying anything you read here.
|
|||
Reply With Quote |
03-14-2012, 09:48 AM | #32 | |||
|
||||
Senior Member (**Dr Smith is named after a character from Lost in Space, not a medical doctor)
|
Thanks, that'll do. Happen to have a couple of statistical mathematicians in the hizzy today...
Doc
__________________
Dr. Zachary Smith Oh, the pain... THE PAIN... Dr. Smith is NOT a medical doctor. He was a character from LOST IN SPACE. All opinions expressed are my own. For medical advice/opinion, consult your doctor. |
|||
Reply With Quote |
04-22-2012, 09:40 AM | #33 | |||
|
||||
Senior Member (**Dr Smith is named after a character from Lost in Space, not a medical doctor)
|
Quote:
I am NOT cured/healed. I am still in constant pain. But my perception of that pain is less, my ability to cope with it better, and I am doing more - I am able to do more - than I have in some considerable time - years. I am back on the pantothenic acid (B5) as well - since mid-late February. acne flares are gone - even during times I should/would ordinarily get them (skin irritation, periods of high stress, dietary triggers), and I'm feeling more like I did before I stopped it - even better since I think it's doing what it's supposed to in fuelling the conversion of pregnenolone and DHEA into other badly deficient/needed/suppressed adrenal hormones. It has recently come to my attention (from a visitor post) that biotin may also be involved in this conversion process. Somehow I missed this in my previous research, but I checked my B-complex supplement, and it only supplies 1/3 of the RDA, so I will be looking into this further, and if warranted, may be adding biotin to my regimen. My next round of blood tests is not for another two-plus months, but I am due to see our next week. Doc
__________________
Dr. Zachary Smith Oh, the pain... THE PAIN... Dr. Smith is NOT a medical doctor. He was a character from LOST IN SPACE. All opinions expressed are my own. For medical advice/opinion, consult your doctor. Last edited by Dr. Smith; 04-22-2012 at 10:36 PM. |
|||
Reply With Quote |
05-17-2012, 08:33 PM | #34 | |||
|
||||
Senior Member (**Dr Smith is named after a character from Lost in Space, not a medical doctor)
|
Started biotin (1000 mcg/day) two weeks ago, to aid in fuelling conversion of pregnenolone and DHEA as mentioned in previous post. Read that biotin and B5 can compete for absorption if taken together, so I'm taking the B5 morning & evening, and the biotin midday. No noticeable difference, so for the time being, I'm just assuming it's doing its thing in the background.
Saw our PCP today. He is delighted with my improvement - "Hey, I'm for whatever works," he says. Got the lab order for blood tests coming up in June, and touched base on other issues. Feeling pretty good, all things considered. Doing more, and in much better spirits. Doc
__________________
Dr. Zachary Smith Oh, the pain... THE PAIN... Dr. Smith is NOT a medical doctor. He was a character from LOST IN SPACE. All opinions expressed are my own. For medical advice/opinion, consult your doctor. |
|||
Reply With Quote |
05-17-2012, 09:57 PM | #35 | |||
|
||||
Wisest Elder Ever
|
I've also read that biotin utilization may be blocked some (not 100%) by lipoic acid use.
So I am ordering it too, from Puritan's this go round. This is the longest I've used lipoic acid.... my previous attempts were brief, because it didn't work= the older version ALA. Biotin is also blocked by uncooked egg whites, and sometimes my boiled eggs are a bit soft and runny... not good for biotin I guess?
__________________
All truths are easy to understand once they are discovered; the point is to discover them.-- Galileo Galilei ************************************ . Weezie looking at petunias 8.25.2017 **************************** These forums are for mutual support and information sharing only. The forums are not a substitute for medical advice, diagnosis or treatment provided by a qualified health care provider. Always consult your doctor before trying anything you read here.
|
|||
Reply With Quote |
05-18-2012, 01:26 AM | #36 | |||
|
||||
Senior Member (**Dr Smith is named after a character from Lost in Space, not a medical doctor)
|
Quote:
Not a fan of runny eggs, so I don't see that as a problem either. Doc
__________________
Dr. Zachary Smith Oh, the pain... THE PAIN... Dr. Smith is NOT a medical doctor. He was a character from LOST IN SPACE. All opinions expressed are my own. For medical advice/opinion, consult your doctor. |
|||
Reply With Quote |
05-18-2012, 07:08 AM | #37 | |||
|
||||
Wisest Elder Ever
|
Here is an article explaining this biotin issue:
http://www.geronova.com/content/lipoic-acid-biotin It also mentions B5.
__________________
All truths are easy to understand once they are discovered; the point is to discover them.-- Galileo Galilei ************************************ . Weezie looking at petunias 8.25.2017 **************************** These forums are for mutual support and information sharing only. The forums are not a substitute for medical advice, diagnosis or treatment provided by a qualified health care provider. Always consult your doctor before trying anything you read here.
|
|||
Reply With Quote |
05-18-2012, 07:44 AM | #38 | |||
|
||||
Senior Member (**Dr Smith is named after a character from Lost in Space, not a medical doctor)
|
Quote:
Quote:
1. I only take RLA in the morning 2. I take B5 morning & evening (12 hr interval) 3. It's been 8 months (B5), and if the RLA were being interfered with, I would think it would have stopped working and the burning would have returned. It hasn't. Doc
__________________
Dr. Zachary Smith Oh, the pain... THE PAIN... Dr. Smith is NOT a medical doctor. He was a character from LOST IN SPACE. All opinions expressed are my own. For medical advice/opinion, consult your doctor. |
|||
Reply With Quote |
05-18-2012, 07:51 AM | #39 | |||
|
||||
Wisest Elder Ever
|
What I am saying by providing the link, is that there is potential for interaction.
Data on supplements is often confusing and people with certain genetic failures, respond differently to them. Just like for drugs....genetic handling of drugs determine their toxicity and/or therapeutic effects or lack thereof. The transport of all 3 of these nutrients in this article may also explain your unique response to them. You may have a genetic need others don't possess. It is not an easy to understand concept. Your bringing up the biotin, opened the door to the biotin controversy, and others who read here might appreciate the link I provided.
__________________
All truths are easy to understand once they are discovered; the point is to discover them.-- Galileo Galilei ************************************ . Weezie looking at petunias 8.25.2017 **************************** These forums are for mutual support and information sharing only. The forums are not a substitute for medical advice, diagnosis or treatment provided by a qualified health care provider. Always consult your doctor before trying anything you read here.
|
|||
Reply With Quote |
05-19-2012, 11:02 AM | #40 | |||
|
||||
Senior Member (**Dr Smith is named after a character from Lost in Space, not a medical doctor)
|
Quote:
If I have some genetic need (and I don't know of any evidence or way to prove that) or if there's some other reason regarding the three supplements, many others have it too, and I thought others might appreciate what I've found, as well as what's working for others that doesn't affect me. The majority - 28 out of 33 (~85%) - in the study reported improvement when taking B5 with RLA. I wish the study was larger and corroborated, but at the moment it's all we've got, and at least it's on people and not rats. Many other people are reporting positive results with B5 for other conditions as well, from chronic acne to CFS to Lupus (SLE), and more. One thing I've observed about claims about B5 is that they all involve large to mega doses. I don't know how I feel about that. Larger doses of other vitamins (B12, D3) are recommended here. They are better studied, and we can only hope that B5 will receive similar attention in the near future; IMO there's a little too much coincidence to dismiss it without a closer look. There is insufficient evidence that B5 does anything for most of its claims, and I admit I'm skeptical about many/most of them myself, but that's not why I'm taking it anyway. It's coincidental that it seems to be helping some of those claims, and I'll take what I can get. Maybe there's something to them, or maybe I'm lucky, but I'm not alone. Also, like B12, C, and some other water solubles, there's no upper limit to dosage, and side effects are genrally negligible until one takes obscenely massive doses, so while it may do nothing, it can't hurt to try it and see. B5 and biotin with adrenal hormones - I don't know if that's being done. I'm doing it myself based on what I've gleaned from looking into it. The adrenal hormones are Doctor Tennant's work, and many, many of his patients are benefitting from that - including at least two I've met here on NT. I think a LOT more chronic pain patients could benefit as well, particularly those that fit the profile - long periods of un(der) treated intractable pain and/or long-term opioid use. This therapy is new, like RLA for PN was at one time. All developments must start somewhere and build. I wish I could say ALC worked for me as well, but it doesn't.
__________________
Dr. Zachary Smith Oh, the pain... THE PAIN... Dr. Smith is NOT a medical doctor. He was a character from LOST IN SPACE. All opinions expressed are my own. For medical advice/opinion, consult your doctor. |
|||
Reply With Quote |
Reply |
|
|
Similar Threads | ||||
Thread | Forum | |||
Hormone Therapy - More from Dr. Tennant | Chronic Pain | |||
White rat preliminary report on light therapy | Parkinson's Disease | |||
Improvement after hormone therapy | Traumatic Brain Injury and Post Concussion Syndrome | |||
Hormone Replacement Therapy | Women's Health |