[vini]

hi all

please see attached schismatics for proposed device for regulating CSF pressure the device consists three chambers one to regulate pressure and act as a reservoir when production / pressure is low and act as an expansion chamber when production / pressure is high this is achieve by means of a flexible diaphragm, the diaphragm is operated by a second diaphragm and chamber filled with saline, the saline as a buffer mimicking the csf pressure and the movement of the pressure + - diaphragm this is also were the pressure sensors are located , above the + - diaphragm is the vacuum chamber this diaphragm is deformed by mechanical means thus achieving pressure / volume changes this is achieved by means of a variable currant electromagnetic solenoid working against a calibrated spring so this can be adjusted as fast as the cpu can vary the currant all the chambers are fitted with monitoring sensors to indicate failure also there is a fail lock device fitted to the compression shaft , also a electromagnetic solenoid pressure relief valve set to fail off set into the csf circulating chamber, also a dosing port , the other two vessels act as a pump to circulate the csf through the device and have no affect on pressure, they operate in the same way as the pressure diaphragm but due to the non return valves act as a pump these are operated by on off electromagnetic solenoids, one is a backup in the event of failure this could also be done with the pressure regulating vessel to improve safety , the device is attached via two shunts this device could be set in silicone and implanted with its micro processor control and power unit out side the body

I hope this device can bring pain relief and mobility to people with CSF pressure problems what led me to design was the post below

thanks for posting a idea,s on treatment thread the device I describe below, would I feel control pressure and maintain pressure at therapeutic high / low or healthy levels , the volume of fluid in our body's is small so such a device could also be small and with technology moving fast and this being such a new field, in the right hands could such a device be developed.


with 30 years in the fire sprinkler industry I know a bit about fluid dynamics so as an engineer faced with pressure fluctuation with in a closed system such as the skull and spine which are constructed of bone that has no expansion property s with its pressure relief valve consisting of a membrane with a set aspiration rate eg non return valve and filter with a set mesh orifices on the outlet side of the system.

On the intake side we have the choroid plexus the manufacturing plant and pump now normally the pump would cut in and cut out on demand by means of a pressure switches sensing high and low pressure as set by the aspiration rate and thus maintaining normal positive pressure at a set value above the ambient blood pressure to maintain the blood brain barrier

transversely from an engineering point of view the choroid plexus, pump could run at a constant flow, the pressure maintained by the aspiration rate by increasing and decreasing the mesh orifice to allow spent CSF to pass to drain thus maintaining system pressure that way or a bit of both ( a pressure relief valve )

fluid dynamics what is pressure = compression of a liquid or gas

measurement PSI KPA bar millibar feet head ect

method fluid compress increase pressure/ expand decrease pressure
increase volume increase pressure/ decrease volume decrease pressure in a restricted flow pressure vessel

constants
pressure vessel bladder/ lining is confined by a structure of greater in tensile strength than the force exerted from within

variables effecting constant pressure
supply and demand
ambient air pressure / blood pressure
ambient temperature /blood temperature
leak

an engineering solution to stabilize pressure would be to to fit an expansion chamber and pressure relief valve the expansion chamber is a vessel that contains a diaphragm when pressure is to high a piston will allow it to expand thus reducing pressure if low pressure is detected the piston compresses the diaphragm increasing the pressure thus maintaining a steady pressure within the system without loss of volume regardless of supply and demand the pressure relief valve only operating when parameters are exceeded so minimal loss of fluid

a leak in the system

this will cause havoc with the pressure in the system the pump will be starting and stopping or running all the time the aspiration rate will be increasing and decreasing the mesh orifice size as pressure is gained and loss,d
the leak is fixed all the settings are wrong, high pressure in the system
I hope that on the horizon there is a expansion chamber and pressure relief valve being developed by a medical team with the technology moving fast with medical implant technology sorry if this seems to over simplify things but its just how i think

kind regards Vini

[kalamity_jane]

vini ... you plan on working on this to get it patented and into production? just curious coz i think it a good idea.

[vini]

hi all

I hope this device can bring pain relief and mobility to people with CSF pressure problems / hart problems the title of this response STANDING ON THE SHOULDERS OF GIANTS was first coined by the great sir Isaac Newton in many aspects this device uses the mechanisms he first described I use the word coined, because this saying also is on the out side edge of our UK two pound coin and replaces the early er Latin inscription SIC VOS NON VOBIS which has a different meaning ? , This concept has come from the artistic creative part of my brain, so like my art remains my intellectual property I am posting it here in creative corner because , I could be way of beam with the whole concept , but would hope it would come to the attention of the medical fraternity with the resources and know how to develop the device for practical applications, the point of these forums is the sharing of information and support I have a CSF leak in my skull, and know of others in great pain who spend there days flat on there backs they come from all walks of life kids young mums and dads and seniors

I would sell the concept /design to any reputable medical institution for the sum of two UK pounds sterling £ 2.00
and that no animial shall suffer pain in the development of the device ( STANDING ON THE SHOULDERS OF GIANTS, SIC VOS NON VOBIS ?

[kalamity_jane]

wow vini, i think that's great...all the best of luck that someone in the medical field picks up on it.

[vini]

hi all

we have only 140 ml of CSF in our body's at any given time, that.s under half a coffee cup, to effect pressure changes in the millibar range, in this volume of fluid the device could be as small as a match box or even smaller we produce and absorb between 600ml and 700ml a day that,s about a pint the device dose not change that, it only circulates CSF through its self so there is no stagnation, similar to our body,s own natural system

please see below info

kind regards Vini

THE NORMAL CSF
The cerebrospinal fluid (CSF) is produced from arterial blood by the choroid plexuses of the lateral and fourth ventricles by a combined process of diffusion, pinocytosis and active transfer. A small amount is also produced by ependymal cells. The choroid plexus consists of tufts of capillaries with thin fenestrated endothelial cells. These are covered by modified ependymal cells with bulbous microvilli. The total volume of CSF in the adult is about 140 ml. The volume of the ventricles is about 25 ml. CSF is produced at a rate of 0.2 - 0.7 ml per minute or 600-700 ml per day. The circulation of CSF is aided by the pulsations of the choroid plexus and by the motion of the cilia of ependymal cells. CSF is absorbed across the arachnoid villi into the venous circulation. The arachnoid villi act as one-way valves between the subarachnoid space and the dural sinuses. The rate of absorption correlates with the CSF pressure. CSF acts as a cushion that protects the brain from shocks and supports the venous sinuses. It also plays an important role in the homeostasis and metabolism of the central nervous system.

CSF from the lumbar region contains 15 to 45 mg/dl protein (lower in childen) and 50-80 mg/dl glucose (two-thirds of blood glucose). Protein concentration in cisternal and ventricular CSF is lower. Normal CSF contains 0-5 mononuclear cells. The CSF pressure, measured at lumbar puncture (LP), is 100-180 mm of H2O (8-15 mm Hg) with the patient lying on the side and 200-300 mm with the patient sitting up.