The short answer is yes, alcohol can impact enzymes. There are cofactor enzymes throughout the body, which are interdependent to the function or dysfunction of p450 enzymes.

For example, the deficient enzyme in AIP Porphyria is essential for heme. Heme is essential to the function of the p450 enzymes. If the enzyme to produce heme is deficient, the p450 pathway is disrupted which in turn, depending on degree of deficiency, may cause neurotoxicity. Mthfr is another more common enzyme.

Stopping alcohol and taking methyl b12 will only help. You may have many other insufficiencies and deficiencies with all the gut issues. I still think you should see a doctor about ruling out autonomic dysfunction. If the mania is not creative busy getting stuff done and more restless, insomnia, wired type it may also indicate autonomic.

Personally, I would ask for autonomic testing, metabolic, electrolytes, emg/ncs and an ekg. It is hard to be your own advocate when you don’t feel well. There are many boards here, with lots of support and information

Fodmap diet has proven helpful for IBS. There are many recipes on Pinterest. A probiotic and l-glutamine may be worth looking into.

There are chronic forms of appendicitis...
http://www.everydayhealth.com/appendicitis/chronic/

However, you used Seroquel for a year or more, yes?
This drug can damage the pancreas, and cause pancreatitis.
If you Google that you will find it listed.
Then the heavy drinking...compounds the problem, and you can get MORE damage to the pancreas. Then you get pain, vomiting, and blood sugar elevations and dips that affect your brain. It is like a domino effect. (excess sweating can be a sign of low blood sugar, or rapid swings down from a high level, as well as from infections).

You have too many serious things going on at once and so you really need a doctor to test for pancreatitis, low B12, elevated white count to see if you have an infection, before you attribute your symptoms as mania, bipolar or whatever.