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Old 07-05-2016, 06:33 AM #1
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As far as your medications are concerned it might help if you looked at the "Interactions Checker" here Drugs.com | Prescription Drug Information, Interactions & Side Effects.

There could be possible negative interactions between your medications - if so, definitely worth discussing with your prescribing doctor.
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Old 07-05-2016, 10:57 AM #2
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I've used another interaction checker in the past, and there doesn't seem to be anything that would cause a reaction like this. Repeatedly warned of seizures in rare cases with the bupropion and the Adderall, though more so in cases in those with neurological disorders.

I've already done research on which medications affect dopamine levels given dopamine in particular seems to screw with the CNS/PNS. The Adderall and bupropion are both Dopamine/Norepinephrine Reuptake Inhibitors. The topiraimate is the only definitive dopamine antagonist that I'm on. Clonazepam potentially has an effect on dopamine levels, but I'll have to talk to neuro about that. I have heard that benzos can affect dopamine levels, but I haven't found definitive evidence either way. The lamotrigine is a sodium channel blocker and glutamate antagonist; irrelevant in what I'm looking for. 2:1 on dopamine uppers to dopamine downers, but I'm not sure what the relative strength of the one dopamine antagonist is to the two DNRIs. More neuro questions as soon as they called me.

...Yes. I am a giant nerd. I'm a psych major too, so I'm extra nerdy here. :P
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Old 07-05-2016, 11:29 AM #3
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Since you are young... I'd look at recent vaccines you may have been given?

Next on the list, which you have not stated yet tested for, is a MTHFR mutation, which inhibits activation of B12 and folic acid to their methyl forms in the body. This is a DNA test.
MTHFR Mutation | MTHFR Gene Mutation | What is MTHFR? - MTHFR.net

This is relatively new but implicated in many hard to diagnose patients with various symptoms. Regular doctors have not yet
informed themselves about this topic, it seems, yet.

What is an MTHFR Gene Mutation? Wellness Mama

Many people who come to these boards today, with continuing trouble finding a diagnosis, have tested positive for this mutation. About 40% of people today have this to some degree.
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Old 07-05-2016, 12:00 PM #4
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mrsD: Thank you for the information. I've had all typical vaccinations, including the HPV vaccines. ...I'm a little skeptical of the information presented given the past attempts at linking vaccines to gene mutations, and this article specifically links this gene mutation to autism... We know how well that went last time.

Regardless, I will look into it. I'm not going to dismiss it until I have sufficient evidence to do so, and there are valid points to the information that I've read so far. I have pulled lab results for low folic acid in the past.

It isn't impossible that some vaccines may cause genetic mutations, necessary or not. Again, thank you for the information. I need all the information that I can get my hands on given the current situation. I'm still afraid of being blown off due to my psychiatric history, so I need to go to the appointment, when they call me, with information and questions to make it very clear that I am tired of dicking around and being ignored because I am psychologically disordered and chose to be diagnosed and treated. Like anyone with any physical disorder would.

Mental health stigma. Have to love it. >_>
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Old 07-05-2016, 12:47 PM #5
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Vaccines are implicated in stimulating autoimmune responses, not gene mutations. If you have some links to those specific mutations I hope you share that here.

DNA mutations are inherited for the most part. Some drugs will damage DNA like fluoroquinolone antibiotics and chemo agents.
I have yet to see DNA damage from vaccines yet. A vaccine works by stimulating the immune system to make antibodies to a particular infectious agent.

Your stubborn anemia is more indicative of low B12 or methylation errors.
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Old 07-05-2016, 01:06 PM #6
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I misread the information given. My bad. I though it was implying that the vaccinations were causing the gene mutations. No surprise there at the moment; again, cognitive function and pretty awful right now. I'll have to go back and re-read for clarification when I'm less disoriented.

I'm aware of the function of vaccines and the origins of mutations both genetic and environmental (radiation/chemo in cancer treatment as you've mentioned, or UV radiation resulting in skin cancer. Grandfather worked in the coal mines back in the day and developed... lymphoma.., I believe, from chemical exposure). Wasn't aware of the specific drugs that were mutagenic, but I remember hearing it in genetics last semester when covering genetic mutations related to specific forms of cancer. The Philadelphia Chromosome and... agh, something else. Anyway, the professor went on a mini-tangent about cancer drugs also causing mutations when covering proto-oncogenes and oncogenes.

I believe they tested B12 levels and they were normal. I'd have to go back and take a look at the labs to know for sure, but I know that folic acid was low at one point. That was mentioned in one of the articles I'd taken a look at. The iron didn't start dropping until I was 17 when my gall bladder was removed, and it didn't get bad until I was 18 or 19. That's when they found the PCOS. Iron infusions last summer at 20. Presumed to be related to that given 3-12 weeks of female hell every two or three months. Was not nice.

Again, thank you for the information. Since I've switched from microbiology to psychology, I've missed the conversations regarding the science behind things. Even if my comprehension is a little low at the present time, I still enjoy it. :33
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Old 07-05-2016, 03:22 PM #7
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I think you need to get your B12 result. The lab ranges go way down still to 200 pg/ml. The new low is now 400pg/ml.

Here is my B12 thread with links you can read:
STICKY - The Vitamin B12 Thread:

This link at the beginning page of that thread discusses this
serious oversight about B12... a doctor who almost died because of it:

Diagnosing and Treating Vitamin B12 Deficiency - YouTube
I only am disappointed that the video does not go into detail about methylcobalamin. Otherwise it is a very good resource.

Vitamin B12 Deficiency - American Family Physician
This is a medical site --over a decade old now, for doctors and nurses.
You have an anemia...that is one clue to what is going on with you perhaps.
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Old 07-05-2016, 03:34 PM #8
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Last edited by mrsD; 07-05-2016 at 03:35 PM. Reason: sorry duplicate
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