I got results with 25 mgs. I LOVE this stuff!! But, the 25 mgs only worked for about 6 months -- and I had to up to 50 mgs. -- which only worked for about 6 months -- had to up to 75 mgs. -- only worked for.........you get the picture. I am now on 125 mgs. Actually, I probably could have continued with the 25 mgs. and had break-through migraines 2 or 3 days a month -- and that would not be bad. I wanted it ALL -- NO MIGRAINES -- so, I keep on upping the dosage. I do not seem to be having ANY side effects at all. I also have Myasthenia Gravis -- and Topamax seems to relieve some of the muscle discomfort in my shoulders and neck.

I started out with the REAL stuff -- when it went generic, I switched -- no problems, works the same for me. Now, here is the STRANGE part -- I have HUGE problems with MOST meds -- Prednisone makes ME suicidal -- I cannot take most of the meds for MG -- so, it is REALLY, REALLY strange that Topamax gives me no trouble at all. I am MORE than a little ticked that I have NOT lost any weight -- LOL!!! And, it makes my hair and nails grow FASTER than ever!!

Did you DRINK enough? I drink water or weak tea ALL day long. Did you try SPLITTING your dose -- half in the morning and half at night? Did they check your blood levels to see how your body was metabolizing the Topamax? Topamax makes your body "acid". I take a Tums at night before I go to bed -- I wonder if that might help you? You might need to research a "low acid diet". I take MY Topamax IN the morning (best for me).