Hi I've been on Clomipramine for about two years now (175 mg up to 250mg) and about 50-100 luvox. I know the luvox increases the blood levels greatly of the clomipramine and i even had toxicity before becasue i had such a high blood level. My pychiatrist told us to taper 50 mg a week or 2 weeks? I dont remember...but anway i was off it eventually for about a month and i had to go bacvk to the hospital becuase i was feeling so terrible and the idiots there didin't even consider that it might have been severe withdrawal symptoms (i couldn't even eat)