Looks like hiccups can be a sympton of MS.

jackD aka (Braindead)


Neurology. 2006 Nov 14;67(9):1684-6.


Pathologic laughing and intractable hiccups can occur early in multiple sclerosis.

de Seze J, Zephir H, Hautecoeur P, Mackowiak A, Cabaret M, Vermersch P.

Department of Neurology, CHU of Lille, France.

Pathologic laughing occurs in approximately 10% of patients with multiple sclerosis (MS), especially when patients have entered the chronic stage. We describe four patients with MS who, at an early stage, developed pathologic laughing associated, in two cases, with intractable hiccups. In two patients, MRI showed an enhanced lesion in the medulla oblongata and the mesencephalon, two regions suspected of being involved in pathologic laughing and intractable hiccups.

Publication Types:
Case Reports

PMID: 17101907 [PubMed - indexed for MEDLINE]
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Neurology. 1979 Jun;29(6):797-801.


Hoquet diabolique: intractable hiccups as a manifestation of multiple sclerosis.

McFarling DA, Susac JO.

In three patients, intractable hiccups occurred as part of the symptomatology of multiple sclerosis. In one patient intractable hiccups were the presenting complaint, and in another patient exacerbations of symptoms were almost always heralded by intractable hiccups. Intractable hiccups occur in a variety of diseases, including many that affect the brainstem and cervical cord, but have not been reported in multiple sclerosis. The hiccup may be a "primitive" gastrointestinal reflex that is disinhibited by lesions such as multiple sclerosis plaques. Carbamazepine was successful in arresting the hiccups in one of the cases presented.

Publication Types:
Case Reports

PMID: 221856 [PubMed - indexed for MEDLINE]