Yes, I have felt that way Judy, and I am very empathetic to your thoughts & emotions.

It is often our circumstances that make us feel so bad/sad, but perhaps a new antidepressant might actually help somewhat? They can lose their effectiveness, I imagine, and a new drug might do what it should.

Are you still having relapses? Sounds like you might be going through a particularly bad time, so it could be . . .?

I was going downhill quite fast in 2004, after a serious of back-to-back attacks. I have felt so much better (EDSS has even improved) since going on LDN. If you are on nothing else, it might be worth a try.

Sorry to hear you are feeling down and having a hard time.

Cherie