fin makes a good point, about being on interferons, if you are.
i've been taking AD's for a very long time and have felt well for as long.
i've had to change my AD a number of times for various reasons.
it may be time for your dr to reevaluate the effectiveness of your AD. sometimes over time they just don't help as much as they once did.

i also am an advocate of therapy. i would consider talking to your dr about this. sometimes you can't see the forest until you're out of the trees.

the goal is to help you feel better.
please keep us posted.