I've done it at home many times. I always have them leave it in because I am a hard stick. The nurse who always came to do my infusions said that her MS patients were a mix of people - some wanted it left in and others wanted it removed every day. I use Glad Press & Seal in the shower because it sticks better. I keep the hep lock thing covered with gauze when not in use.

In my opinion, it is much nicer to do at home. You can really be more comfortable and the stuff always wipes me out, so it is nicer to not have to drive back and forth.