I'm another one who can say that those itching and burning sensations and the huge lumps from Copaxone shots really do go away as time goes by.

I've been on Copaxone for nearly 3 years now, and I hardly ever have any reactions at all to the shots any more. In fact, I often can't find where the needle went in by the time I'm reaching for the cotton ball to put over the injection site. If I feel around I can sometimes find a tiny bump.

Every once in a while a shot will hurt but nothing like the first few months. And I do still have lumps with the arm shots.

Good luck on Copaxone!

Pud - Rebif I took at night 1/2 hr after 2 ibuprofen and 1.5 hrs before sleep.
Sides were horrible during titration pack, were gone 2 months in.
Tysabri isnt much more effective on me then Rebif and not as good as C was the 2 1/2 yrs i took C.

Lady - when did C change formula?

I went from C to Rebif about 2 months ago and I hate Rebif right now. I totally understand what people mean when they talk about the treatment being worse than the disease now. I was on C for 3 years and the reactions were at most a minor nuisance. Since I have gone on Rebif, I had been sick for about 4 of the 7 weeks I have been on it (which is highly unusual for me...I am usually the last to get sick). I woke up for 2 hours Monday morning with violent chills that no amount of extra blankets could fix and an hour later I had a 99.7 fever.

I can't think of a 7 week period in my life where I have consistently felt worse than I have on Rebif. I hate this disease! I felt so strong right before I had to go off of C too...

I say pre med with up to 800mg ibuprofen 1/2 hr before shot.
My 1st Rebif ever was 1/4 dose and I figured ah i wont need ibuprofen..
I had those chills batman. I know. 400mg ibu was procedure there on out.
Friend of mine took 800mg ibu every time.