Hi Lyn!
Are you taking anything for spasticity? Does it help with the problem you describe? Have you increased your activity lately? Have you had any back trouble lately?

I'm asking because these are the first questions your doc is going to ask. It's entirely possible he will also call for a full brain/spine MRI, not only to check for enhancing lesions, but also for sciatic nerve impingement or lumbar/sacral spinal vertebrae shifting or breakdown.

I had exactly what you describe a few years ago and I assumed it was MS. My neurologist told me never assume it's MS, rule out other factors, and after MRI, I found out it was sciatica from a bulging disk in my spine. I had to do some exercises, take anti-inflammatory drugs for a few weeks and change the way I was doing some daily activities. Sally gave good advice, always let your neuro know when something changes and lasts more than 24-48 hours.

Now that the test for anti-JC antibodies has been approved, it should be available to everyone on Tysabri. It's a simple blood draw and results are available within 4 weeks. If it's a concern, your neuro should be able to order the test for you.

Let us know how it goes for you!