NeuroTalk Support Groups - Dextromethorphan and MS:

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- - Dextromethorphan and MS: (https://www.neurotalk.org/multiple-sclerosis/153405-dextromethorphan-ms.html)

There is nothing keeping anyone from using low dose DM OTC.

The quinidine is the RX part, and works by blocking the metabolism of the DM. If you wanted you could just take the DM in low dose more often. Quinidine is not an innocuous drug. And this Nuedexta is a radical new concept of including a low dose, possibly problematic drug which affects the metabolism of the second drug to keep the blood levels in a range to work.

The whole thing IMO is iffy, and potentially dangerous. This is MY opinion, but using DM alone is still an option. You just take it a bit more often is all.
http://the-scientist.com/2011/07/11/...rup-treats-ms/

This is the original paper abstract:
http://www.ncbi.nlm.nih.gov/pubmed/21704706
.1mg per kilogram in animals... a kilogram is 2.2lb. Which works out to 7mg/150lb person if this study generalizes to humans. This is really a small amount, of DM.

Nuedexta was designed for people with pseudobulbar affect...which is inappropriate emotional lability.

Some of the anti-inflammatory studies on PD and MS are not yet approved for humans using low dose DM.

Thanks MrsD!

That is why I was put on Neudexta (PBA/pseudo bulbar affect). Talk about another "surprise" to go with polka dotted brain... While it did not eliminate the episodes of PBA 100% it did make the frequency much less and those that did pop up easier to hide or make a joke of. PBA stinks - especially as I do a alot pf public speaking and teaching.

Question: I took 1 capsult of Neudexta (20mg Dextromethorphan HBr and 10mg Quinidine) every 12 hours, how much dex. would I take every 12 hours? I just seem to have lost my ability to do simple math sense my last flare. {or I am just getting stupid in my 40s:rolleyes:}

thanks all

Thank you & I'd like to get some tomorrow. Brands mentioned have many variations. Can someone state exact brand & variation that contains only what we're after?

Quote:

Originally Posted by RLSmi (Post 786153)

I've been using low dose dextrometorphan as an alternative to LDN for Parkinson's disease for more than six years of the ten years I have been diagnosed, with what I feel is good success.

I buy over-the-counter pediatric preparations (PediaCare, Triaminic, etc) that contain 7.5 mg of dextromethorphan hydrobromide per 5 ml (1 tsp). It is important that the cough syrup NOT contain any other active ingredient such as guafinesin, polystyril, antihistamines. I take 1/2 tsp every night at bedtime, which should contain 3.75 mg of the drug.

Dextromethorphan (DM) and naltrexone are both morphinans which have been shown to be powerful anti-inflammatory drugs, demonstrated by the research by Dr. J.S. Hong to be especially effective in neural tissues of the CNS. Because of the long history of safety of DM, I feel very comfortable in using this inexpensive, non-prescription drug as a neuroprotective agent.

Robert Smith

How do you come up with 3.75mg of the dextromethorphan hydrobromide? I read the article and did not see the amount?
Are these effects the same as using LDN?

And why would you use the dextromethorphan/hydrobromide INSTEAD of the LDN?

Probably because you can get the dextromethorphan over the counter as a cold syrup. For LDN, you need a prescription.

Still awaiting everyone's favorite so I don't waste time trying to read labels in store. Thanks.

Bought grocery store brand today. I bought adult version for strength per mL which contains dextromethorphan only. 3mg per mL vs 1.5mg mL of kiddie formula.
"The quinidine is the RX part"...I saw it mrsD on store shelf, no rx required. I bought the one without it based on Roberts post.
I can use syringe to drop an exact dose every night in my mouth. Couldn't sleep on LDN so i'll try this. Try 2.5mL for 7.5mg? I'm about 155lbs & in shape.

Let us know how it works for you..:)

What's it supposed to do anyway?

Quote:

Originally Posted by EddieF (Post 819848)

Bought grocery store brand today. I bought adult version for strength per mL which contains dextromethorphan only. 3mg per mL vs 1.5mg mL of kiddie formula.
"The quinidine is the RX part"...I saw it mrsD on store shelf, no rx required. I bought the one without it based on Roberts post.
I can use syringe to drop an exact dose every night in my mouth. Couldn't sleep on LDN so i'll try this. Try 2.5mL for 7.5mg? I'm about 155lbs & in shape.

I don't know what you saw, but quinidine is NOT on any store shelf. It is a very strong heart drug, in fact not much used any more. It is in the Nuedexta because it impairs the metabolism of DM and keeps it in the blood stream a long time.
Nuedexta contains both DM and quinidine (which is supposed to be low dose).

Robert's experience is for PD. He thinks other ingredients like antihistamines combined with DM change its action.
I have found that DM helps my PN pain in my feet. It is not a huge effect but does help. I use a product to help clear my sinuses called Mucus relief DM... 1/2 tablet at bedtime.
I get it OTC at WalMart, at a reasonable price. It also has guaifenesin in it to help dissolve thick mucus.