I think I recall posting this before?

http://neurotalk.psychcentral.com/thread153404.html

DM also helps with chronic pain management if used properly.

*tkrik getting ready to go get some cough syrup*

That's awesome mrsD! Who would have thought that a little cough syrup can be a neuroprotective agent. Thanks for posting this.

I've been using low dose dextrometorphan as an alternative to LDN for Parkinson's disease for more than six years of the ten years I have been diagnosed, with what I feel is good success.

I buy over-the-counter pediatric preparations (PediaCare, Triaminic, etc) that contain 7.5 mg of dextromethorphan hydrobromide per 5 ml (1 tsp). It is important that the cough syrup NOT contain any other active ingredient such as guafinesin, polystyril, antihistamines. I take 1/2 tsp every night at bedtime, which should contain 3.75 mg of the drug.

Dextromethorphan (DM) and naltrexone are both morphinans which have been shown to be powerful anti-inflammatory drugs, demonstrated by the research by Dr. J.S. Hong to be especially effective in neural tissues of the CNS. Because of the long history of safety of DM, I feel very comfortable in using this inexpensive, non-prescription drug as a neuroprotective agent.

Robert Smith

Robert - Thank you for your post. I was kind of wondering about all that and your posted answered it. I will try the kinds that you recommended. It does seem like an inexpensive and safe treatment option. I am glad to hear it is working for you for your Parkinson's.

You mention not to get ones with other active ingredients and I was just wondering why that is? The reason I ask is that I have seasonal allergies and it would be great to get a 2 for 1, so to speak, medicine - a neuroprotective and an antihistamine. Do the other ingredients reduce the neuroprotective effect?

tkrik - Because the amount of DM appropriate for the low-dose effect is so small, I doubt that you would get enough antihistamine to be effective. The usual dose of the dilute pediatric preparations for cough is a couple of teaspoons at 6-8 hr intervals; way more than used in the low-dose approach.
Some of the additives, especially polystyril, result in a slow release of the DM, which defeats the quick "peak" of the med required for the desired effect. I learned this directly from Dr. Hong who has done much of the research on suppression of CNS inflammation with morphinans like DM and naltrexone at very low doses.

I'm on LDN and loving it. I wonder what the effect would be, if I took both? Double your pleasure-double your fun or maybe one canceling out the other?

How do you come up with 3.75mg of the dextromethorphan hydrobromide? I read the article and did not see the amount?
Are these effects the same as using LDN?

And why would you use the dextromethorphan/hydrobromide INSTEAD of the LDN?

Probably because you can get the dextromethorphan over the counter as a cold syrup. For LDN, you need a prescription.