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Old 12-02-2011, 09:56 PM #1
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I looked it up poochie, that sucks. the good news is, you shouldn't have to wean off of Prozac, as you do with other ADs. It has a long half life or something like that. I'm on 40 mgs.

Ask your pharmacist or Doc if there is something you can take to take the place of Prozac, that doesnt interact negatively with Plavix.

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Last edited by SallyC; 12-03-2011 at 09:14 AM.
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Old 12-02-2011, 10:16 PM #2
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call your local pharmacist. You will be pleasantly surprised to discover how much he/she knows.
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Old 12-03-2011, 06:55 AM #3
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We have to be our own best advocates, always informed and educated. I like my neuro and PCP but feel "It's my body and we work as a team", in the end no one now what and hos as much as really concerned and involved us. They get really busy and don't have all the answers.

Had a wheelchair repair guy here who in the end wasn't really helpful. In the end I ended up problem solving as It's me who can't walk and is so dependent on my chair and do know it and this life very intimately.
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Old 12-03-2011, 07:07 AM #4
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This is not easy, wheelchair guy is not one of my favorites (We've had previous encounters). I had to hold my ground dealing with this petty tyrant know-it-all and he maybe interpreted strength and assertiveness as rude. Jerk.
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Old 12-03-2011, 07:47 AM #5
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This is the official reason for the interaction:

http://www.drugs.com/interactions-ch...5-360,1115-648

SSRI drugs also increase bleeding risk:

This is another search using Lexapro as a substitute:
http://www.drugs.com/interactions-ch...13-565,705-360

It explains the bleeding risks.

Wellbutrin may be an option for you since it does not affect serotonin. However, metabolism of Wellbutrin is affected, so lower doses may be used. (but the doctor may refuse to give this anyway with the interaction):

http://www.drugs.com/interactions-ch...05-360,440-203

So 3 separate reasons for 3 separate antidepressants combined with Plavix.

Tapering down with Prozac takes time, since it is a long acting drug in the body. Some doctors allow tryptophan OTC to help with this. But I don't know if that will affect the Plavix as well.
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Old 12-03-2011, 09:12 AM #6
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This is what I heard, but I haven't tried to come off of Prozac......and when I came off Paxi, 4-5 yrs ago, Doc replaced it with Prozac and I had no withdrawal sx from Paxil.

Perhaps if you start another AD, you will not have any trouble?

Quote:
Discontinuation syndrome
Several case reports in the literature describe severe withdrawal or discontinuation symptoms following an abrupt interruption of fluoxetine treatment.[24] However, various studies have shown that the side effects of the fluoxetine discontinuation are uncommon and mild, especially compared to paroxetine, venlafaxine and fluvoxamine, probably due to the relatively long pharmacological half-life of fluoxetine.[24] One of the recommended strategies for the management of discontinuation syndrome with other SSRIs is to substitute fluoxetine for the original agent, in cases where tapering off the dose of the original SSRI is ineffective.[25][26] The double-blind controlled studies support this opinion. No increase in side effects was observed in several studies when the treatment with fluoxetine was blindly interrupted for a short time (4–8 days) and then reinstated, this result being consistent with its slow elimination from the body. More side effects occurred during the interruption of sertraline (Zoloft) in these studies, and significantly more during the interruption of paroxetine.[27] In a longer, 6 week-long, blind discontinuation study, an insignificantly higher (32% vs 27%) overall rate of new or worsened side effects was observed in the group that discontinued fluoxetine than in the group that continued treatment. However, a significantly higher 4.2% rate of somnolence at week 2 and 5-7% rate of dizziness at weeks 4-6 were reported by the patients in the discontinuation group. This prolonged course of the discontinuation symptoms, with dizziness persisting to the end of the study, is also consistent with the long half-life of fluoxetine in the body.[28] According to a 2007 summary report of available evidence, fluoxetine has the lowest incidence of discontinuation syndrome among several antidepressants including paroxetine and venlafaxine. [29] See also SSRI discontinuation syndrome.
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