AMantadine worked ok for me but can no longer take it. I did not get wired but found I needed less naps and felt less tired (as in I could soldier on easier without my daily nap)

I ended up getting a weird lacey pattern develop on my legs (as in red purple lines snaking in a pattern up & down my lower extremeties) and a lot of swelling in feet and legs. My husband said it reminded him of ugly version of fishnet stockings on pudgy feet and legs LOL

The decrease in fatigue (I hate that euphamism!) wore off after a few months being on it. A side benefit is I never got the flu while on it :-)

Amantadine is cheap, relatively easy to tolerate and helps some MSers. It is not "approved" to treat MS induced fatigue as that side benefit was discovered after/about the same time it became available in generic form (thus no reason or $ incentive for original maker to spend big bucks on getting FDA approval for MS).