I had this terribly and suddenly...with my lisinopril reaction. That is a special case I guess. I couldn't even tolerate bedcovers in the coldest part of winter!

But also one very good remedy is magnesium. People low in this mineral (found in nuts, beans, yogurt, oatmeal) get muscle cramping and twitching. You can use a topical lotion/cream (which I do now) or a product called SlowMag (WalMart carries it) twice a day, or a good chelate like citrate, gluconate, or glycinate,etc. OXIDE does not work...it is not absorbed and remains in the bowel as a laxative.

When do you take the Baclofen? Right before you go to bed?
If that is the case, try altering your timing and see if that changes anything. Baclofen is a GABA agonist with complex actions.

I try to remember to take the Baclofen around 7 PM. That way it has an hour or so to get into my system. If I don't go to bed before 10 or 11 I usually take another one.

Oh, btw, I stopped Lisinopril, too. I haven't started a different HBP med yet but expect my PCP to suggest one.

I can't imagine that I'm not getting enough magnesium. I eat nuts (walnuts, almonds, cashews) plus I take a good multi-vitamin along with my slew of supplements. I might just try the Slow-Mag, though. Can't hurt.

I am having good results so far with only 25mg of atenolol at
bedtime. I measure my BP at home 3 x a day.
So far so good. However, I have found over the years that
there can be tolerance to blood pressure drugs.

I was waking up on that lisinopril about 2-3 hrs after taking it
and kicking and tearing up the bed something awful! The cats
stopped sleeping with me! Now that seems all gone, and must have been the swelling and bradykinin reactions.
That whole crisis with that drug was awful!

I guess it will be a long time now before my furry friends
return .

Good article concerning RLS. Many causes of it.

http://www.mayoclinic.com/health/res...ndrome/DS00191

I know a few who take Mirapex and find it helps quite a bit. I just live with it.