Most people do have one side that is bigger than the other. Sometimes it's not noticeable and other times it is. My left calf has always been bigger than my right. However, it's my left leg that is weaker than my right. My right hand is slightly larger than my left and it's my right hand that, by testing, is severely impaired. My left foot is bigger than my right foot and when buying shoes I try on the left side first.

Strength wise and in terms of MS, my left side is where I have most of my trouble from the eyes all the way down to my feet. My right side acts up every now and then with nerve pain and spasticity but not as much as my left side.

When talking ambidextrous, I am right-hand dominant but can use my left hand effectively, not as good as my right but I can use it.