Hello everyone. I am new to this forum. I have been dx with MS since Dec 1998 and have been on Avonex since March of 1999.

My reason for joining is for support and with this visit is to address an issue I am having and hopefully get a response from someone that has had similar experience or some expertise.

After almost 15 years of weekly IM injections, I have suddenly (past 6 weeks) had my needles rejected by a large and hard jumping mass of muscle) and so much shooting pain it brought tears.

Today, after yet another attempt to my right thigh it happened again, I could not even inject nor was I able to get it past a few layers of skin. It hurt!!

Could this be damage to my muscles after so many years of IM injections, could it be atrophy or scar tissue?

Thank you.