This is my first time posting in the forum. I am desperately seeking advice. I am beginning the 1000mg prednisone regime. Dose is 500mg x2 daily. I am looking for advice as to when is the best time to take to avoid adverse effects. What to expect. I am very nervous as I have read some of the posts. Please all tips and advice are greatly appreciated. I have MS and am in the middle if a flare, specificAlly diagnosed with optic neuritis. I have just started a new job and ideally would like to begin the regime Friday am in order to complete the treatment over the weekend. Advice and tips would be greatly appreciated. Thanks so much.