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High dose thiamine improves fatigue in multiple sclerosis (July 16, 2013) Although blood thiamine and thiamine pyrophosphate levels were within normal limit in all the patients, high-dose thiamine therapy administered orally or parenterally led to an appreciable improvement of the fatigue. The absence of apparent decrease in blood thiamine despite the presence of symptoms referable to a mild thiamine deficiency suggests that these patients may have a dysfunction of the mechanisms of intracellular transport or structural enzymatic abnormalities. The administration of large quantities of thiamine was effective in reversing the fatigue in MS, suggesting that the abnormalities in thiamine-dependent processes could be overcome by diffusion-mediated transport at supranormal thiamine concentrations. http://www.ncbi.nlm.nih.gov/pubmed/23861280 http://attackms.com/blog/2012/11/14/...ms-warriorette Last edited by zanpar321; 02-02-2015 at 02:37 PM. |
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"Thanks for this!" says: | SallyC (02-02-2015) |
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