I just began with Tecfidera last Tuesday. I took it at 21 PM and 3 hours later at 0 AM I had the flushing, great heat and itching that lasted for an hour. Then yesterday I took an aspirin half an hour before tecfidera and...tadaaa, no flushing. I didn't take the aspirin today and no flushing too.

My schedule is:
- 1st week = 120 mg at night
- 2nd week = 120 mg in the morning, 120 mg at night
- 3rd week = 120 mg in the morning, 240 mg at night
- 4th week = 240 mg in the morning, 240 mg in the night

That's all! Greetings!

Congratulations on solving that problem!

From my experience with MS drugs--3 years on Avonex, 3 years on Copaxone--I have the impression that it pays to keep tinkering with the schedule and with how you deal with the side effects. If one thing doesn't work, you move on to another way and keep on doing that until you have a system you can get along with.

With both Copaxone and Avonex, the tendency to have bad side effects was especially noticeable at first but after a few doses things got better. Maybe that's what's going on with you and Tecfidera.

It's great to hear from you agate.

Yes, at the beginning, I preferred Plegridy as it was 1 injection each 14 days, but the neuro said that Plegridy, in reality, is just the same as Avonex, and if Plegridy had an effectivity of 30% Tecfidera is on 50%, so she recommended to begin with tec first.

Plegridy is also interferon beta-1a, like Avonex, but it's pegylated. They've done some tinkering with the molecules:

PEGylation - Wikipedia

Reducing the dosage frequency would make life easier. I recall doing an Avonex shot once a week and would have been glad if it had been less often.