Hey Carolyn,

With Rebif, make sure you stay really hydrated. I still get a headache if I'm not great with the water, both day of and day after shot. I actually try to get an extra 16 oz. in. most days for that reason.

I did feel a difference after bumping up from 22 to 44. While some people don't need it, I still need to take Alleve before the shot, and then the following morning. If not, I run a slight fever. So I've found if I get the Alleve in ahead of it, the fever doesn't appear.

Hope your adjustment goes quick. If you have any questions, feel free to PM me.

Kathy