Good for you for trying, and sorry it didn't work out.

Have you considered Copaxone? Apparently the side-effects aren't as bad for some people.

Cherie

you're right to try something different.
sometimes meds don't work and the side effects aren't worth the benefits.

please keep us posted.
glad you're feeling good.

Hi Keith..
I totally understand what you've been going thru, as I went thru the same on Rebif for nearly a year. When I couldn't take anymore, and realized the medication was making me feel worse than the illness it was supposedly helping, my neuro had me stop taking it. I, too, felt almost instantly better. He put me on Copaxone, and I never had a bad reaction to it. The Rebif was definately working, because the follow-up MRI I had before quiting showed improvement in the old and nothing new, but I felt like a zombie..a sick zombie..I hope you find something that works well for you!

That's it to a T PE. My MRI's have shown improvement and nothing new. But a zombie is right or a zombie hopped up on amphetatimines. There's a mental picture for ya! lol

Doesn't copaxone cause fatigue too? I'm liking what I'm hearing from people I know that are doing tysabri. Leaning that way but I have to wait till my next neuro appt. in March.

I appreciate the feedback from everyone though, it's hard to pick - they all suck is what it amounts to. We are lucky to have them available though. My uncle just had roids and he's jacked up from 30 years of them now.

Copaxone can cause fatigue, again, varies from person to person. I quit taking DMD's last summer, and felt a little more awake. This is not a course of action I would recommend to anyone, but being progressive, it seemed pointless to experience any more fatigue than a I had to since there's nothing that shows DMD's are effective for progressive MS anyway (nothing I've heard of, that is)..That's not to say I wouldn't try something again in the future if that view changed. It's a tough choice each of us has to make. Seems like there are no "easy" choices with this disease..

Kao - That's great! Sometimes a change in meds is what we need. I am glad that has worked for you.

I did the same with Paxil. Although I still get fatigued is nothing like what it was when I was on Paxil. I felt so much better within a couple of weeks of not taking it.

No, the Copaxone does not make me tired or fatigued. For me, going on Copaxone was a good decision. My last MRI, when compared to last years, showed no changes. I was thrilled.

We all have to do what works best for us and what we are comfortable with. It may sound weird but after I take my Copaxone I meditate and think of the meds going to my brain and stopping MS in it's tracks. The mind too can be powerful medicine.

Good luck in your decision process. Keep us posted.