I was on Avonex for 2-1/2 years and my DH did my shots Friday evening before bed so I could sleep through the side effects. If it were me, I would postpone a week so you could do it on Friday evening and not have to rush to work.

As someone else said, meds effect everyone different. I always had side effects and I distinctly remember the side effects from the first shot being the worst. I dosed up on ibuprofen and drank lots of fluids on shot night. When it seemed my body developed a tolerance to the ibuprofen, I started taking Theraflu about an hour before my shot.

Good luck!