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Old 03-31-2008, 03:02 PM #1
color color is offline
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color color is offline
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Quote:
Originally Posted by greta View Post
No problem. I was dx'd in 2001. I had headaches that were lasting up to 3 weeks in duration and were starting to hit back to back. I suspected it was a sleep issue, and the neuro agreed but wanted to do an MRI just to make sure there wasn't a brain tumor. No brain tumor but several silent lesions. In 2003, I got a second opinion, another MRI, and an LP. The neuro confirmed MS, but called it infraclinical/subclinical since I hadn't had an exacerbation (only changes were additional silent lesions).

So far it's stayed that way. I started a DMD in 2003 and there have been no changes to my MRI since then. In total, I have about 10 or so lesions on my brain. I have yet to have an exacerbation and have no symptoms or other MS issues like fatigue or heat intolerance. I still work 40 hours/week and have an active life, for which I'm truly thankful.

I take a DMD which requires injections 3x/week. I've never had a spinal MRI - I've only had brain ones. I'm heading in for my annual MRI tomorrow morning. Keeping my fingers crossed that it shows a quiet brain for another year...
Thanks -- I guess I'm really hung up on my family history, mainly because I have one affected aunt who is convinced that she has MS (from Grandmom), and that my disorder and my brother's were merely passed down through my mother as MS. When I say "affected," this is what I mean re: symptoms: gait difficulty, imbalance, neuropathy, slurred speech, coordination issues (swallowing, fine motor skills, etc.), fatigue, vision...and the list goes on and on with neurologic problems! The real clincher is that as I mentioned before, no one (mother, aunt, brother, myself) has brain lesions -- the only thing they found is cerebellar atrophy. Hmmmm??

Anyway, good luck tomorrow!

Take care,
Christina
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Old 03-31-2008, 04:17 PM #2
michael178 michael178 is offline
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the autosomal dominant part of the Dx means that it takes one and only one parent to pass along the problem, that 50% of children will inherit it. As far as MS goes, it is not that strongly geneticaly linked; at most there probably is a predisposition towards getting the disease from a parent.

And I would be cautious about too strong of a correlation between MRI spots, no matter where they occur, and symptoms, there is not that sort of linkage yet. And spots on an MRI do not necessarily mean MS, there is a large group of diseases called leukodystrophies, for instance, that cause myelin problems. They are fatal genetic diseases, and they cause all of the symptoms you describe.

In addition to an MRI, a positive lumbar puncture is needed to Dx MS. It sound like the genetic testing is a hunt for something else, something worse than MS.
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