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Old 10-24-2006, 11:58 AM #15
Harry Z Harry Z is offline
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Join Date: Sep 2006
Location: London, Canada
Posts: 241
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Harry Z Harry Z is offline
Member
 
Join Date: Sep 2006
Location: London, Canada
Posts: 241
15 yr Member
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Quote:
Originally Posted by kingrex View Post
In all fairness, that patient was already severely immunosuppressed when Tysabri was started. So that's really not a fair case of monotherapy. Nobody has died from monotherapy to date.
Rex,

I know that is a statement that has been made before but in actual fact, this Crohn's patient had stopped using Infliximab 20 months earlier and had stopped Azathioprine 8 months before being hospitalized. Unless those drugs stay in one's system for that huge length of time, the only drug the patient was using at the time of getting PML was Tysabri.

Another note of interest...this patient was relatively healthy at the time of going on Tysabri, only suffering from the problems associated with Crohn's which had been with him for several years. He had been involved in the Tysabri trial earlier but was on the placebo.

Harry
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